Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Yanying Miao"'
Autor:
Xin Hu, Guo-Li Zhao, Meng-Xi Xu, Han Zhou, Fang Li, Yanying Miao, Bo Lei, Xiong-Li Yang, Zhongfeng Wang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progressive apoptotic death of retinal ganglion cells (RGCs). Although the mechanisms underlying RGC apoptosis in gl
Externí odkaz:
https://doaj.org/article/ef5a238d7f8343608ed3099530a3ba4c
Autor:
Shuo Cheng, Hong-Ning Wang, Lin-Jie Xu, Fang Li, Yanying Miao, Bo Lei, Xinghuai Sun, Zhongfeng Wang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here, we investigated ho
Externí odkaz:
https://doaj.org/article/f373704aa90e45808655fe75b3458779
Autor:
Shu-Ting Liu, Shu-Min Zhong, Xue-Yan Li, Feng Gao, Fang Li, Meng-Lu Zhang, Ke Zhu, Xing-Huai Sun, Xin Wang, Yanying Miao, Xiong-Li Yang, Zhongfeng Wang
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract It was previously shown that EphB/ephrinB reverse signaling in retinal ganglion cells (RGCs) is activated and involved in RGC apoptosis in a rat chronic ocular hypertension (COH) model. In the present work, we first show that ephrinB/EphB fo
Externí odkaz:
https://doaj.org/article/70b724b467f74cfc950dd0e3e0046f31
Autor:
Feng Gao, Fang Li, Yanying Miao, Lin-Jie Xu, Yuan Zhao, Qian Li, Sheng-Hai Zhang, Jihong Wu, Xing-Huai Sun, Zhongfeng Wang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Our previous studies have demonstrated that activation of group I metabotropic glutamate receptors downregulated Kir channels in chronic ocular hypertension (COH) rats, thus contributing to Müller cell gliosis, characterized by upregulated
Externí odkaz:
https://doaj.org/article/4d741ed90df54a81afe982c0306825bf
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 2, Pp 455-464 (2011)
Glaucoma, mainly caused by high intraocular pressure (IOP), is characterized by apoptotic death of retinal ganglion cells (RGCs). We investigated the possible involvement of cyclin-dependent kinase 5 (Cdk5) and its activator p35, which have been impl
Externí odkaz:
https://doaj.org/article/f00b3d335e2b43d59606fe28778ceb87
Publikováno v:
Neural Plasticity, Vol 2013 (2013)
DBA/2J mouse has been used as a model for spontaneous secondary glaucoma. Here, we investigated changes in expression of NMDA receptor (NMDAR) subunits and Cdk5/p35/NMDAR signaling in retinas of DBA/2J mice using Western blot technique. The protein l
Externí odkaz:
https://doaj.org/article/b174fcc1b6c4401ebe95d1427b0c789d
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42318 (2012)
We investigated possible involvement of a calpain/p35-p25/cyclin-dependent kinase 5 (Cdk5) signaling pathway in modifying NMDA receptors (NMDARs) in glutamate-induced injury of cultured rat retinal neurons. Glutamate treatment decreased cell viabilit
Externí odkaz:
https://doaj.org/article/bf02401cc7fe44e0802d21f6c596fabf
Autor:
Guo‐Li Zhao, Hong Zhou, Yun‐Hui Guo, Shu‐Min Zhong, Han Zhou, Fang Li, Bo Lei, Zhongfeng Wang, Yanying Miao
Publikováno v:
Glia. 71:1502-1521
Autor:
Zhi‐Xin Zhou, Lin‐Jie Xu, Hong‐Ning Wang, Shuo Cheng, Fang Li, Yanying Miao, Bo Lei, Feng Gao, Zhongfeng Wang
Publikováno v:
Glia. 71:720-741
Deficiency of glutamate transporter GLAST in Müller cells may be culpable for excessive extracellular glutamate, which involves in retinal ganglion cell (RGC) damage in glaucoma. We elucidated how GLAST was regulated in rat chronic ocular hypertensi
Autor:
Xinghuai Sun, Lin-Jie Xu, Hong-Ning Wang, Yanying Miao, Fang Li, Bo Lei, Shuo Cheng, Zhongfeng Wang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Neuroinflammation plays an important role in the pathogenesis of glaucoma. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine released from activated retinal glial cells in glaucoma. Here, we investigated how TNF-α