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Akademický článek

Functional cooperation between ATG7/autophagy and the PALB2 tumor suppressor in mitochondrial regulation, redox homeostasis, and neuronal health

Autor: Yanying Huo, Akshada Sawant, Eileen White, Bing Xia

Publikováno v: Autophagy Reports, Vol 1, Iss 1, Pp 234-237 (2022)

In a recently published study, we described a genetic interaction and functional cooperation between Atg7, an essential autophagy gene, and Palb2, a breast cancer susceptibility gene, in the maintenance of mitochondrial function, redox homeostasis, a

Externí odkaz: https://doaj.org/article/6c2703cde3cf4bdfa20b805ccfbccbbd

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Akademický článek

Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

Autor: Amar H. Mahdi, Yanying Huo, Ying Chen, Pier Selenica, Anchal Sharma, Elise Merritt, Nicola Barnard, Chang Chan, Shridar Ganesan, Jorge S. Reis-Filho, Britta Weigelt, Subhajyoti De, Bing Xia

Publikováno v: Genes and Diseases, Vol 9, Iss 3, Pp 807-813 (2022)

The BRCA1-PALB2-BRCA2 axis, or the BRCA pathway, plays key roles in genome stability maintenance and suppression of breast and several other cancers. Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brca1, Brc

Externí odkaz: https://doaj.org/article/37376583475844e2887748811286f349

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Akademický článek

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Autor: Yanying Huo, Pier Selenica, Amar H. Mahdi, Fresia Pareja, Kelly Kyker-Snowman, Ying Chen, Rahul Kumar, Arnaud Da Cruz Paula, Thais Basili, David N. Brown, Xin Pei, Nadeem Riaz, Yongmei Tan, Yu-Xiu Huang, Tao Li, Nicola J. Barnard, Jorge S. Reis-Filho, Britta Weigelt, Bing Xia

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)

Abstract Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Palb2, and Brca2, individually and in combination, along with one copy of Trp53, in the mamma

Externí odkaz: https://doaj.org/article/0e18ff09a2e84f079cd0677a6df9cca3

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Akademický článek

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration.

Autor: Yanying Huo, Akshada Sawant, Yongmei Tan, Amar H Mahdi, Tao Li, Hui Ma, Vrushank Bhatt, Run Yan, Jake Coleman, Cheryl F Dreyfus, Jessie Yanxiang Guo, M Maral Mouradian, Eileen White, Bing Xia

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010138 (2022)

The PALB2 tumor suppressor plays key roles in DNA repair and has been implicated in redox homeostasis. Autophagy maintains mitochondrial quality, mitigates oxidative stress and suppresses neurodegeneration. Here we show that Palb2 deletion in the mou

Externí odkaz: https://doaj.org/article/a14fbad6b37441618cc40a94f6c51743

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