Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yanying Dai"'
Autor:
Amna Siddiqui, Halil Dundar, Jyoti Sharma, Aneta Kaczmarczyk, Josh Echols, Yanying Dai, Chuanxi Richard Sun, Ming Du, Zhong Liu, Rui Zhao, Tim Wood, Shalisa Sanders, Lynn Rasmussen, James Robert Bostwick, Corinne Augelli-Szafran, Mark Suto, Steven M. Rowe, David M. Bedwell, Kim M. Keeling
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4521 (2023)
Mucopolysaccharidosis I-Hurler (MPS I-H) is caused by the loss of α-L-iduronidase, a lysosomal enzyme that degrades glycosaminoglycans. Current therapies cannot treat many MPS I-H manifestations. In this study, triamterene, an FDA-approved, antihype
Externí odkaz:
https://doaj.org/article/c098b3027c4442ee84030dff8169fc5b
Autor:
Josh Echols, Amna Siddiqui, Yanying Dai, Viktoria Havasi, Richard Sun, Aneta Kaczmarczyk, Kim M. Keeling
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of
Externí odkaz:
https://doaj.org/article/1c26265435ab476aa88fa28cb689bd0e
Autor:
Kim M Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan, Balachandra Chenna, Jeremy Clark, Valery Belakhov, Jeyakumar Kandasamy, Sadanandan E Velu, Timor Baasov, David M Bedwell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60478 (2013)
Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression o
Externí odkaz:
https://doaj.org/article/65b49f1f65d24a4cb10e23580a3d869b
Autor:
Aneta Kaczmarczyk, Yanying Dai, Richard Sun, Amna Siddiqui, Josh Echols, Viktória Havasi, Kim M. Keeling
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of
Publikováno v:
Journal of endocrinology and diabetes mellitus
Previous studies demonstrate that kudzu root extract and its major isoflavone (puerarin) improve glucose metabolism in animal models of insulin resistance and type 2 diabetes; however, these beneficial effects have not been investigated in normal gly
Autor:
Alireza Arabshahi, J. Michael Wyss, Ning Peng, Jeevan K. Prasain, Scott H. Carlson, Stephen Barnes, Yanying Dai, Ray Moore
Publikováno v:
Journal of Agricultural and Food Chemistry. 57:7268-7273
The present study tested the long-term effects of dietary kudzu root extract supplementation on the regulation of arterial pressure, plasma glucose and circulating cholesterol in stroke-prone spontaneously hypertensive rats (SP-SHR). Female SP-SHR we
Publikováno v:
Journal of Macromolecular Science, Part B. 48:723-735
Microphase and macrophase separation phenomena can simultaneously appear in ABA/C copolymer blend systems due to the immiscibility among monomers A, B, and C. In this work, the surface morphologies and compositions of ABA/C blend thin films confined
Autor:
Robert J. Bridges, Fuquan Chen, Yanying Dai, Steven M. Rowe, Xiaojiao Xue, David M. Bedwell, Ming Du, Jeong S. Hong, Valery Belakhov, Jochen Schacht, Timor Baasov, Venkateshwar Mutyam, Liping Tang, Moran Shalev, Silpak Biswas, Laura A. Jackson
New drugs are needed to enhance premature termination codon (PTC) suppression to treat the underlying cause of cystic fibrosis (CF) and other diseases caused by nonsense mutations. We tested new synthetic aminoglycoside derivatives expressly develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd60151a0e171101e0cc9f6d6da01e6
https://europepmc.org/articles/PMC4068923/
https://europepmc.org/articles/PMC4068923/
Autor:
Jeyakumar Kandasamy, Kim M. Keeling, Trenton R. Schoeb, David M. Bedwell, Gwen Gunn, Valery Belakhov, Yanying Dai, Ming Du, Timor Baasov
Nonsense suppression therapy is a therapeutic approach aimed at treating genetic diseases caused by in-frame premature termination codons (PTCs; also commonly known as nonsense mutations). This approach utilizes compounds that suppress translation te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3a14d0ec1d77d62993c9cea1e32e8e
https://europepmc.org/articles/PMC3943726/
https://europepmc.org/articles/PMC3943726/
Autor:
J. Michael Wyss, Ning Peng, Dario A. Vitturi, Tim M. Townes, Bessy Thrash-Williams, Chiao-Wang Sun, Rakesh P. Patel, Victoria M. Harper, Balu K. Chacko, Yanying Dai, Nadiezhda Cantu-Medellin
The β93 cysteine (β93Cys) residue of hemoglobin is conserved in vertebrates but its function in the red blood cell (RBC) remains unclear. Because this residue is present at concentrations more than 2 orders of magnitude higher than enzymatic compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fa53955563e0d1ebf5d7fb701704bb
https://europepmc.org/articles/PMC3821075/
https://europepmc.org/articles/PMC3821075/