Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yanyang Nan"'
Autor:
Wenjing Xue, Caili Xu, Kaiqi Zhang, Lu Cui, Xiting Huang, Yanyang Nan, Dianwen Ju, Xusheng Chang, Xuyao Zhang
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Claudin18.2 (CLDN18.2) is overexpressed in cancers of the digestive system, rendering it an ideal drug target for antibody-drug conjugates (ADCs). Despite many CLDN18.2-directed ADCs undergoing clinical trials, the inconclusive underlying me
Externí odkaz:
https://doaj.org/article/1c6884e23f074c82bad904974747cf43
Autor:
Caili Xu, Xiting Huang, Qinchao Hu, Wenjing Xue, Kaicheng Zhou, Xingxiu Li, Yanyang Nan, Dianwen Ju, Ziyu Wang, Xuyao Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117550- (2024)
Pancreatic cancer, characterized by a dismal prognosis and limited treatment options, persists as a formidable challenge in oncology. Trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugates have achieved great success in solid tu
Externí odkaz:
https://doaj.org/article/d27020e0913948fc9462fb4fa69449f4
Autor:
Yu Bai, Tao Wu, Jun Lin, Shuwen Xu, Xian Zeng, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Mengyang Li, Yanyang Nan, Xiaozhi Hu, Kaicheng Zhou, An Zhu, Zihan Dou, Zhonglian Cao, Xumeng Zhang, Yuanzhen Zhang, Xuebin Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background The main challenge against patients with cancer to derive benefits from immune checkpoint inhibitors targeting PD-1/PD-L1 appears to be the immunosuppressive tumor microenvironment (TME), in which IL-33/ST2 signal fulfills critical functio
Externí odkaz:
https://doaj.org/article/638af0fc590f47d4ba79bf0e0c80b015
Autor:
Yichen Wang, Yanyang Nan, Chunguang Ma, Xiaolin Lu, Qian Wang, Xiting Huang, Wenjing Xue, Jiajun Fan, Dianwen Ju, Dingwei Ye, Xuyao Zhang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-10 (2024)
Abstract Research and development on Nectin-4 antibody-drug conjugates (ADC) have been greatly accelerated since the approval of enfortumab vedotin to treat uroepithelial cancer. During the course of this study, we identified that autophagy serves as
Externí odkaz:
https://doaj.org/article/77357d89c42e4cefac8fc93cf70a5378
Autor:
Xiaozhi Hu, Yanyang Nan, Yuting Zhang, Jiajun Fan, Hanqi Wang, Yu Bai, Yuanzhen Zhang, Xuyao Zhang, Zeguo Zhu, Zhonglian Cao, Xiaomiao Ye, Tao Wu, Shuwen Xu, Zhengyu Wu, Wei Hu, Dianwen Ju
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107486- (2024)
Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute to the upregulation of CD47 exp
Externí odkaz:
https://doaj.org/article/637d954985274bcfaf351c2a9e188bf5
Autor:
Yu Bai, Yanyang Nan, Tao Wu, An Zhu, Xinlei Xie, Yun Sun, Yong Deng, Zihan Dou, Xiaozhi Hu, Rongrui Zhou, Shuwen Xu, Yuanzhen Zhang, Jiajun Fan, Dianwen Ju
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Non‐alcoholic fatty liver disease (NAFLD) is a prominent cause of various chronic metabolic hepatic diseases with limited therapeutics. Rubicon, an essential regulator in lysosomal degradation, is reported to exacerbate hepatic steatosis i
Externí odkaz:
https://doaj.org/article/7076b9e7f384429c8ad5b42cfcce2c86
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2152 (2024)
Background: Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate. Therefore, it is necessary to investigate other suitable immunotherapeutic targets and strat
Externí odkaz:
https://doaj.org/article/8db267586fa24262b4b3f9c641417b78
Autor:
Yuting Zhang, Weijuan Xin, Xiaozhi Hu, Hanqi Wang, Xiaomiao Ye, Caili Xu, Yanyang Nan, Zhengyu Wu, Dianwen Ju, Jiajun Fan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-11 (2023)
Abstract Macrophages are the origin of most foam cells in the early stage of atherosclerotic plaques. However, the mechanism involved in the formation of macrophage-derived foam cell formation remains unclear. Here, we revealed that the hedgehog (Hh)
Externí odkaz:
https://doaj.org/article/8467d5e7cf3b48dbb5475d6c97d4b959
Autor:
Yu Bai, Rongrui Zhou, Xinlei Xie, An Zhu, Yanyang Nan, Tao Wu, Xiaozhi Hu, Zhonglian Cao, Dianwen Ju, Jiajun Fan
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1118 (2024)
Acute liver failure (ALF) is a serious inflammatory disorder with high mortality rates, which poses a significant threat to human health. The IL-33/ST2 signal is a crucial regulator in inflammation responses associated with lipopolysaccharide (LPS)-i
Externí odkaz:
https://doaj.org/article/b4ca49e5a0fe44118a177d8dfc376f81
Autor:
Zhonglian Cao, Hui Zhao, Jiajun Fan, Yilan Shen, Lei Han, Guangjun Jing, Xian Zeng, Xin Jin, Zeguo Zhu, Qi Bian, Yanyang Nan, Xiaozhi Hu, Xiaobin Mei, Dianwen Ju, Ping Yang
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract The pathogenesis of diabetic kidney disease (DKD) is complicated. Current clinical treatments fail to achieve satisfactory efficacy in the prevention of DKD progression, it urgently needs novel and effective treatment for DKD. In this study,
Externí odkaz:
https://doaj.org/article/0de5f18b146b4cb391f39ab3c1f381b1