Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Yanyan Tudor"'
7
High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms
Autor: Antony Symons, Kaylee Choi, Hyun Yong Jin, Yanyan Tudor, Brian A. Sparling, Zhifei Shao, Joseph G. McGivern
Publikováno v: SLAS Discovery. 25:215-222
The real-time quantification of target engagement (TE) by small-molecule ligands in living cells remains technically challenging. Systematic quantification of such interactions in a high-throughput setting holds promise for identification of target-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4069a97dfef1264f1a88f19a1612be9
https://doi.org/10.1177/2472555219893277
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8
3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase
Autor: David Powers, Guo-Qiang Cao, Scott Middleton, Lisa Sherman, Kelvin Sham, Dawei Zhang, Partha P. Chakrabarti, Faye Hsieh, Andrew Tasker, Yanyan Tudor, Bradley Henkle, Shimin Xu, Lu Min Wong, Ryan Wurz, Liping H. Pettus, Matthew R. Lee, Robert M. Rzasa, Violeta Yu, Christiaan J. M. Saris, Matthew H. Plant, Rashid Syed
Publikováno v: Journal of Medicinal Chemistry. 51:6280-6292
The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087b9c4f5722d23b003b38ab86133ff
https://doi.org/10.1021/jm8005405
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9
Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit
Autor: Ning Chen, Andrea Itano, Randall W. Hungate, Ryan White, Yang Xu, Matthew H. Plant, Yanyan Tudor, Yen Nguyen, Roxanne Kunz, Perry M. Novak, Kristin Meagher, Essa Hu, Jason Brooks Human, Shaun Flynn, Gordon Ng, Xuxia Zhang, Violeta Yu, Roland Burli, Douglas A. Whittington, Andrew Tasker
Publikováno v: Journal of Medicinal Chemistry. 51:3065-3068
Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81447f11bfae7a4d16eb01799010756e
https://doi.org/10.1021/jm800188g
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