Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Yanwen, Duan"'
Autor:
Zhoukang Zhuang, Wenping Kong, Zhongqing Wen, Nian Tong, Jing Lin, Fan Zhang, Zhiying Fan, Liwei Yi, Yong Huang, Yanwen Duan, Xiaohui Yan, Xiangcheng Zhu
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Anthraquinone-fused enediynes (AFEs) are excellent payloads for antibody-drug conjugates (ADCs). The yields of AFEs in the original bacterial hosts are extremely low. Multiple traditional methods had been adopted to enhance the pr
Externí odkaz:
https://doaj.org/article/f308de08a1c74e6889ca58ff96e8b3c3
Publikováno v:
Bioengineering, Vol 11, Iss 11, p 1128 (2024)
Strain robustness and titer improvement are major challenges faced in the industrial development of natural products from Streptomyces. Tiancimycins (TNMs) produced by Streptomyces sp. CB03234 are promising anticancer payloads for antibody-drug conju
Externí odkaz:
https://doaj.org/article/583b52dd607d4da78e15e5683788e231
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract Although natural products are essential sources of small‐molecule antitumor drugs, some can exert substantial toxicities, limiting their clinical utility. Anthraquinone‐fused enediyne natural products are remarkably potent antitumor drug
Externí odkaz:
https://doaj.org/article/7e9737916a6447819e52c1898529a284
Publikováno v:
Engineering Microbiology, Vol 4, Iss 1, Pp 100121- (2024)
Natural product biosynthesis is controlled at multiple levels. Characterization of naturally occurring promoters has facilitated the study of the synthetic biology of natural products. Herein, we report the discovery of two high-yield actinomycin D (
Externí odkaz:
https://doaj.org/article/451d1e66a2334110a974bca3b7a10d59
Publikováno v:
Molecules, Vol 29, Iss 9, p 1982 (2024)
Chalkophomycin is a novel chalkophore with antibiotic activities isolated from Streptomyces sp. CB00271, while its potential in studying cellular copper homeostasis makes it an important probe and drug lead. The constellation of N-hydroxylpyrrole, 2H
Externí odkaz:
https://doaj.org/article/9e65d3718a2b4c51818d8d446537ab2a
Publikováno v:
Foods, Vol 13, Iss 6, p 840 (2024)
The purpose of this study was to evaluate the efficacy of ethanol extracts from Torreya grandis seed (EST) as a functional food in hyperuricemia mice. We investigated EST by analyzing its chemical composition. Using a mouse model of hyperuricemia ind
Externí odkaz:
https://doaj.org/article/cb74032bbab34d85badc9118d681fd8b
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background The anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising potentials as payloads of antitumor antibody–drug conjugates. Despite many efforts, the
Externí odkaz:
https://doaj.org/article/db7d1f6315854f2f9f6d70f86b72a230
Autor:
Danfeng Cao, Jie Yang, Youchao Deng, Meng Su, Yeji Wang, Xueqiong Feng, Yi Xiong, Enhe Bai, Yanwen Duan, Yong Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/23fc6fe9be26407b82b0a76c3ed73bfd
Autor:
Jingyan Zhang, Ying Sun, Yeji Wang, Xin Chen, Lu Xue, Jingjing Zhang, Xiangcheng Zhu, Yanwen Duan, Xiaohui Yan
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-14 (2021)
Abstract Background Rubiginones belong to the angucycline family of aromatic polyketides, and they have been shown to potentiate the vincristine (VCR)-induced cytotoxicity against VCR-resistant cancer cell lines. However, the biosynthetic gene cluste
Externí odkaz:
https://doaj.org/article/a4070d37d1fe4763b9807488c45bb034
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2820 (2022)
Sinomenine (SIN) is a benzyltetrahydroisoquinoline-type alkaloid isolated from the dried plant root and stem of Sinomenium acutum (Thumb.) Rehd.et Wils, which shows potent anti-inflammatory and analgesic effects. As a transforming disease-modifying a
Externí odkaz:
https://doaj.org/article/d5d1de00894d4bc9b573c17c1e6dbd8b