Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yanshen Guo"'
Autor:
Yanling Zhang, Yafei Cao, Xia Wu, Zhenghui Chen, Bowen Chen, Anhui Wang, Yanshen Guo, Wei Chen, Ruolan Xue, Zihua Liu, Yuanpei Li, Tian Li, Ruiqin Cheng, Ning Zhou, Jing Li, Yuan Liu, Xiaohui Zhao, Huixin Luo, Ming Xu, Houhua Li, Yiqun Geng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Deep understanding of sugar metabolite-protein interactions should provide implications on sugar metabolic reprogramming in human physiopathology. Although tremendous efforts have been made for determining individual event, global profiling
Externí odkaz:
https://doaj.org/article/48f8ea1be10f463ca368fdcf07cceb44
Design and Synthesis of Arylamidine Derivatives as Serotonin/Norepinephrine Dual Reuptake Inhibitors
Publikováno v:
Molecules, Vol 24, Iss 3, p 497 (2019)
To improve the in vivo antidepressant activity of previously reported serotonin (5-HT) and norepinephrine (NE) dual reuptake inhibitors, three series of arylamidine derivatives were designed and synthesized. The in vitro 5-HT and NE reuptake inhibito
Externí odkaz:
https://doaj.org/article/66a26c8262e348c5af2591b211391558
Publikováno v:
Tetrahedron. 72:4091-4102
A series of novel OSW-1 analogues were synthesized by coupling disaccharides (2-O-4-methoxylbenzoyl-β- d -xylopyranosyl-(1→3)-2-O-acetyl-α- l -arabinopyranosyl) or (2-O-4-(E)-cinnamoyl-β- d -xylopyranosyl-(1→3)-2-O-acetyl-α- l -arabinopyranos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3074d9b17b4e4cf7daff4703a17f3f2d
https://doi.org/10.1016/j.tet.2016.05.049
https://doi.org/10.1016/j.tet.2016.05.049
Publikováno v:
Journal of Physics: Conference Series. 1637:012065
It will cause some problems like improper way of lightning protection and improper height of lightning rod in the design for direct lightning flash protection of satellite antenna, which may increase the probability of lightning strike, due to the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f60729b2391525f6945e34468e80d0
https://doi.org/10.1088/1742-6596/1637/1/012065
https://doi.org/10.1088/1742-6596/1637/1/012065
Autor:
Yanshen Guo, Decai Fu, Yan Sun, Chong-Jing Zhang, Bailing Xu, Jing Jin, Chen Xiaoguang, Chang Liu, Lina Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:2797-2807
A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC(50) value at the level of 10(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648aeb2a83248ccf4bee4151d0a2a686
https://doi.org/10.1016/j.bmc.2011.03.058
https://doi.org/10.1016/j.bmc.2011.03.058
Publikováno v:
Journal of Molecular Graphics and Modelling. 25:289-295
Phosphomannose isomerase is a zinc metalloenzyme that catalyzes the reversible isomerization of mannose-6-phosphate and fructose-6-phosphate, and the three-dimensional (3D) structure of human phosphomannose isomerase has not been reported. In order t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cced0db6a0a5c95ce42789563939360
https://doi.org/10.1016/j.jmgm.2006.01.001
https://doi.org/10.1016/j.jmgm.2006.01.001
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:866-874
A series of azaindole-α-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure–activity relationship was developed for PPARα/γ dual agonism. One of the synthesized compound 7a was identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4867c644ef6217c9fde95cd1a1f3e844
https://doi.org/10.1016/j.bmc.2005.09.040
https://doi.org/10.1016/j.bmc.2005.09.040
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5424-5434
Docking simulations and three-dimensional quantitative structure-activity relationship (3D-QSAR) analyses were conducted on a series of indole amide analogues as potent histone deacetylase inhibitors. The studies include comparative molecular field a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0799050ea6da700fa26ca3fbff249210
https://doi.org/10.1016/j.bmc.2005.05.016
https://doi.org/10.1016/j.bmc.2005.05.016
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
A series of piperine derivates (1–19) have been designed, synthesized and evaluated in vitro for their monoamine oxidase (MAO) A and B inhibitory activity and selectivity. It is worth noting that most of the small amine moieties substituted on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169920bfeb983750f86b511c77bcacf8
https://pubmed.ncbi.nlm.nih.gov/22475561
https://pubmed.ncbi.nlm.nih.gov/22475561
Publikováno v:
Steroids. 76(1-2)
A facile and efficient way for the synthesis of cholestane and furostan saponin analogues was established and adopted for the first time. Following this strategy, starting from diosgenin, three novel cholestane saponin analogues: (22S,25R)-3β,22,26-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f58829bdbf9874abf15e05a0ab8f6c7
https://pubmed.ncbi.nlm.nih.gov/20728459
https://pubmed.ncbi.nlm.nih.gov/20728459