Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yanran Deng"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Insect wing development is a fascinating and intricate process that involves the regulation of wing size through cell proliferation and apoptosis. In this study, we find that Ter94, an AAA-ATPase, is essential for proper wing size dependentl
Externí odkaz:
https://doaj.org/article/a9d8af92951e46c4bf4e1475e240b0f7
Autor:
Xiaohan Sun, Dafa Zhou, Yuanfei Sun, Yunhe Zhao, Yanran Deng, Xiaolin Pang, Qingxin Liu, Zizhang Zhou
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114584- (2024)
Summary: The transcriptional coactivator Yorkie (Yki) regulates organ size by promoting cell proliferation. It is unclear how cells control Yki activity when exposed to harmful stimuli such as oxidative stress. In this study, we show that oxidative s
Externí odkaz:
https://doaj.org/article/506e64de83324aa6b4b5ff6669e6538c
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-14 (2024)
Abstract The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding CUL3. Reported point mutations always occ
Externí odkaz:
https://doaj.org/article/1875bb8c488f4870921702c120e99d62
Autor:
Yunhe Zhao, Dezhen Peng, Yanyun Liu, Qian Zhang, Bin Liu, Yanran Deng, Wenhao Ding, Zizhang Zhou, Qingxin Liu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-12 (2022)
Abstract Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of great significance for therapeutic strategies. Here, we find that the ubiquitin-specific prote
Externí odkaz:
https://doaj.org/article/ccdddca3265d4d648d4d20091bb4ab0e
Autor:
Yan Ding, Guiping Wang, Meixiao Zhan, Xiaohan Sun, Yanran Deng, Yunhe Zhao, Bin Liu, Qingxin Liu, Shian Wu, Zizhang Zhou
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell m
Externí odkaz:
https://doaj.org/article/9549fca3d5f74864b8029b48f1e17014
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer
Publikováno v:
Investigational New Drugs. 38:515-524
E3 ligases are a class of critical enzymes that can catalyse the transfer of ubiquitin (Ub) from an E2 enzyme to the substrate and are essential to cellular processes. The E3 ligase HUWE1 (also known as ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776b1abea7b03c6ba3060d60c13ea0ef
https://doi.org/10.1007/s10637-020-00894-6
https://doi.org/10.1007/s10637-020-00894-6
Autor:
Zhao Yunhe, Yan Ding, Meixiao Zhan, Guiping Wang, Qing-Xin Liu, Yanran Deng, Xiaohan Sun, Bin Liu, Zizhang Zhou, Shian Wu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842b4a8799011ec4c4b8e7f4faed197e
https://doi.org/10.1038/s41419-021-04423-y
https://doi.org/10.1038/s41419-021-04423-y
Autor:
Yanran Deng, Dezhen Peng, Jing Xiao, Yunhe Zhao, Wenhao Ding, Shengtao Yuan, Li Sun, Jian Ding, Zizhang Zhou, Meixiao Zhan
Publikováno v:
Cell death and differentiation.
Although the Hedgehog (Hh) pathway plays an evolutionarily conserved role from Drosophila to mammals, some divergences also exist. Loss of Sufu, an important component of the Hh pathway, does not lead to an obvious developmental defect in Drosophila.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0d4023e4465d5f9cab10fd6a253774
https://pubmed.ncbi.nlm.nih.gov/36220888
https://pubmed.ncbi.nlm.nih.gov/36220888