Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yannis, Sotsios"'
Autor:
Boris V. Skryabin, C Cromme, Adelheid Korb-Pap, Viktor Wixler, Eugen Retser, Christina Koers-Wunrau, Thomas Pap, Yannis Sotsios, Lars Meyer, Dominique Baeten, Rhonda Bassel-Duby, Katja Mühlenberg, Kurt Redlich, Stephan Ludwig, Neil Smyth, Jessica Bertrand, Paul P. Tak, Birgit Niederreiter
Publikováno v:
Annals of the rheumatic diseases, 74(12), 2216-2223. BMJ Publishing Group
ObjectiveWe analysed the role of the adaptor molecule four-and-a-half Lin11, Isl-1 & Mec-3 (LIM) domain protein 2 (FHL2) in the activation of fibroblast-like synoviocytes in human rheumatoid arthritis (RA) and tumour necrosis factor α (TNFα)-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77920748d82b2d1a6a5ffe16020585c0
https://doi.org/10.1136/annrheumdis-2013-205061
https://doi.org/10.1136/annrheumdis-2013-205061
Autor:
Subhra Lahiri, Ashutosh Vyas, Yannis Sotsios, Sunil Shekar, Villoo Morawala-Patell, Srinivas Ireni, Rajesh Ullanat, Geetha Sodhan, Sunit Maity, Gopal Dyaga, Nirmala Nair, Denis C. Maria
Publikováno v:
Biologicals. 39:384-395
Etanercept is a soluble tumor necrosis factor (TNF) receptor originally approved for treatment of moderate-to-severe rheumatoid arthritis, juvenile rheumatoid arthritis, and psoriatic arthritis. We have developed a non-innovator version of the recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ed9ad90ebc4a102a1d5db67264e081
https://doi.org/10.1016/j.biologicals.2011.08.014
https://doi.org/10.1016/j.biologicals.2011.08.014
Publikováno v:
Lancaster University-Pure
Stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 are a multifunctional chemokine/receptor system with essential roles in the development of the immune system and other aspects of embryogenesis, including vascularization and organ developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db0d129e303d933b39bb382f267ef4
https://doi.org/10.4049/jimmunol.170.8.4021
https://doi.org/10.4049/jimmunol.170.8.4021
Autor:
Yannis Sotsios, Stephen G. Ward
Publikováno v:
Immunological Reviews. 177:217-235
Chemokines can couple to distinct signalling pathways that have been demonstrated to mediate not only migration, but also cell growth and transcriptional activation. One particular signalling pathway, namely that controlled by the lipid kinase phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d61f65e559e29a25709e70923b65e8
https://doi.org/10.1034/j.1600-065x.2000.17712.x
https://doi.org/10.1034/j.1600-065x.2000.17712.x
Autor:
Yannis Sotsios, Stephen G. Ward
There is increasing evidence that T lymphocytes play a central role in regulating both the initial and chronic inflammatory cascades of allergic asthma (1,2) and can also regulate baseline airway responsiveness in mouse models of asthma (3). In parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b9c4e0063be1ebdaf104bec27394ea2
https://doi.org/10.1385/1-59259-151-5:205
https://doi.org/10.1385/1-59259-151-5:205
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e225688a6dd0c0eb1cd90c5fb3b4d7bb
https://pubmed.ncbi.nlm.nih.gov/14573921
https://pubmed.ncbi.nlm.nih.gov/14573921
Publikováno v:
Immunology Letters. 56:103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6542b7f8ad457a708c0871b87790c9
https://doi.org/10.1016/s0165-2478(97)85408-9
https://doi.org/10.1016/s0165-2478(97)85408-9
Publikováno v:
Chemistry & Biology. (3):207-213
At least one Holy Grail for many academic researchers and pharmaceutical research divisions alike has been to identify therapeutically useful selective PI3K inhibitors. There are several different but closely related PI3Ks which are thought to have d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbeb1187d0b2f4f85ae676b9948017c
Autor:
Sarah Allden, Tim Bourne, Maria C Denis, Ksanthi Kranidioti, Alexander Vugler, Stevan Shaw, Gillian Watt, Remi Okoye, Zofia Stencel, Adrian Moore, Yannis Sotsios
Publikováno v:
Journal of Translational Medicine
Background Novel molecules that specifically target human TNFα in rheumatoid arthritis pose problems for preclinical assessment of efficacy. In this study collagen antibody-induced arthritis (CAIA) has been induced in human TNFα transgenic mice to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697b3a978200963510a7fa2687f42cab