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Autor:
Carme, Balaña, Jose Luis, Ramirez, Miquel, Taron, Yannis, Roussos, Aurelio, Ariza, Rosa, Ballester, Carme, Sarries, Pedro, Mendez, Jose Javier, Sanchez, Rafael, Rosell
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4)
In glioblastoma multiforme (GBM), the cytotoxic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolamide is dependent on O(6) alkylation, which correlates inversely with expression of the DNA repair enzyme O(6)-methyl-guanine-DNA methyl