Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yannik Bollen"'
Autor:
Yannik Bollen, Joris H Hageman, Petra van Leenen, Lucca L M Derks, Bas Ponsioen, Julian R Buissant des Amorie, Ingrid Verlaan-Klink, Myrna van den Bos, Leon W M M Terstappen, Ruben van Boxtel, Hugo J G Snippert
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001527 (2022)
CRISPR-associated nucleases are powerful tools for precise genome editing of model systems, including human organoids. Current methods describing fluorescent gene tagging in organoids rely on the generation of DNA double-strand breaks (DSBs) to stimu
Externí odkaz:
https://doaj.org/article/cd66eca306e549c4a4b1983de5881ebb
Autor:
Sippe G. de Vries, Wigard P. Kloosterman, Holger Rehmann, William Cross, Myrna van den Bos, Sander Boymans, Bingxin Lu, Susanne M.A. Lens, Hugo J. Snippert, Yannik Bollen, Markus J. van Roosmalen, Maximilian Mossner, Nicolle Besselink, Ellen Stelloo, Christopher Kimberley, Edwin Cuppen, Chris P. Barnes, Petra van Leenen, Bas Ponsioen, Ana C. F. Bolhaqueiro, Koen C. Oost, Bastiaan van der Roest, Trevor A. Graham, Andrea Sottoriva, Geert J. P. L. Kops, Leon W.M.M. Terstappen
Publikováno v:
Nature Genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, w
Autor:
Yannik Bollen
From the moment of conception, every human being is in the process of developing cancer. Whether or not you will ultimately be diagnosed with this disease is simply a matter of whether something else kills you first. Cancer is not one disease. Rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1226d4733ca7c84b3b32fdb6ca200a70
https://research.utwente.nl/en/publications/karyotype-diversification-in-colorectal-cancer(3027df19-816f-4009-bdc8-1593ea0bac1f).html
https://research.utwente.nl/en/publications/karyotype-diversification-in-colorectal-cancer(3027df19-816f-4009-bdc8-1593ea0bac1f).html
Publikováno v:
Nucleic Acids Research
Model systems with defined genetic modifications are powerful tools for basic research and translational disease modelling. Fortunately, generating state-of-the-art genetic model systems is becoming more accessible to non-geneticists due to advances