Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yannick Regin"'
Autor:
Ignacio Valenzuela, Yannick Regin, Andre Gie, David Basurto, Doaa Emam, Marianna Scuglia, Katerina Zapletalova, Marnel Greyling, Jan Deprest, Johannes van der Merwe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Fetal growth restriction (FGR) remains one of the main obstetrical problems worldwide, with consequences beyond perinatal life. Animal models with developmental and structural similarities to the human are essential to understand FGR long-te
Externí odkaz:
https://doaj.org/article/805c952a10e943d1af6964b0d2e643a2
Autor:
Felix R. De Bie, Yannick Regin, Antoine Dubois, Marianna Scuglia, Tomohiro Arai, Ewout Muylle, David Basurto, Marius Regin, Siska Croubels, Marc Cherlet, Emily A. Partridge, Karel Allegaert, Francesca M. Russo, Jan A. Deprest
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 115996- (2024)
Congenital diaphragmatic hernia (CDH) is a congenital malformation characterized by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. Pulmonary hypertension represents the major cause of neonatal mortality and morbidity. Prenatal
Externí odkaz:
https://doaj.org/article/c9b0548dce864408ab855b63cc4e3b0e
Autor:
Ignacio Valenzuela, David Basurto, Yannick Regin, Andre Gie, Lennart van der Veeken, Simen Vergote, Emma Muñoz-Moreno, Bartosz Leszczynski, Birger Tielemans, Greetje Vande Velde, Jan Deprest, Johannes van der Merwe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Fetal growth restriction is one of the leading causes of perinatal mortality and morbidity and has consequences that extend well beyond the neonatal period. Current management relies on timely delivery rather than improving placental functio
Externí odkaz:
https://doaj.org/article/bf367b1fdc4146d4a7da0780406be9fe
Autor:
Jonas Labode, David Haberthür, Ruslan Hlushchuk, Yannick Regin, Andre George Gie, Thomas Salaets, Jaan Toelen, Christian Mühlfeld
Publikováno v:
Physiological Reports, Vol 11, Iss 12, Pp n/a-n/a (2023)
Abstract The mammalian pulmonary vasculature consists of functionally and morphologically heterogeneous compartments. When comparing sets of lungs, for example, in disease models or therapeutic interventions, local changes may be masked by the overal
Externí odkaz:
https://doaj.org/article/4b95f0b3784a4c15a162ac586e86b183
Autor:
Katerina Zapletalova, Ignacio Valenzuela, Marnel Greyling, Yannick Regin, Cristian Frigolett, Ladislav Krofta, Jan Deprest, Johannes van der Merwe
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2685 (2023)
Fetal growth restriction (FGR) remains without an effective prenatal treatment. Evidence from murine FGR models suggests a beneficial effect of prenatal pravastatin. Since the rabbit hemodichorial placenta more closely resembles the human condition,
Externí odkaz:
https://doaj.org/article/79a5d9e534a443c9a3182e8da2718ca9
Autor:
Thomas Salaets, Margo Aertgeerts, André Gie, Janne Vignero, Derek de Winter, Yannick Regin, Julio Jimenez, Greetje Vande Velde, Karel Allegaert, Jan Deprest, Jaan Toelen
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical research in this area
Externí odkaz:
https://doaj.org/article/d1b0261419d542c6a15eec5f4867dd65
Fetal Growth Restriction Impairs Lung Function and Neurodevelopment in an Early Preterm Rabbit Model
Autor:
Ignacio Valenzuela, Katerina Zapletalova, Marnel Greyling, Yannick Regin, Andre Gie, David Basurto, Jan Deprest, Johannes van der Merwe
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 139 (2023)
We previously reported the multi-system sequelae of fetal growth restriction, induced by placental underperfusion, in near-term born rabbits, in the immediate neonatal period and up to pre-adolescence. Herein, we describe the pulmonary and neurodevel
Externí odkaz:
https://doaj.org/article/2eff6563bf9148c2835aed5b6ba1f5c4
Autor:
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1507 (2022)
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia. However, the pulmonary outcomes of postnatal TZDs have not b
Externí odkaz:
https://doaj.org/article/3deb22c045194f439472a544de6d3be1
Autor:
Thomas Salaets, Bieke Tack, André Gie, Benjamin Pavie, Nikhil Sindhwani, Julio Jimenez, Yannick Regin, Karel Allegaert, Jan Deprest, Jaan Toelen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239562 (2020)
Reproducible and unbiased methods to quantify alveolar structure are important for research on many lung diseases. However, manually estimating alveolar structure through stereology is time consuming and inter-observer variability is high. The object
Externí odkaz:
https://doaj.org/article/12be68fb98b0421397caa937a319bf40
Autor:
Giacomo Rößler, Jonas Labode, Yannick Regin, Thomas Salaets, André Gie, Jaan Toelen, Christian Mühlfeld
Publikováno v:
Journal of Histochemistry & Cytochemistry. 71:259-271
Bronchopulmonary dysplasia (BPD) is a developmental disorder of infants born prematurely, characterized by disrupted alveolarization and microvascular maturation. However, the sequence of alveolar and vascular alterations is currently not fully under