Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy

Autor: Yannick Pereira, Julien Laffaire, Gwenaël Primas, Emmanuel Vial, Jonas Mandel, Serguei Nabirotchkin, Aude Milet, Esther Graudens, Mickaël Guedj, Fabrice Glibert, Ilya Chumakov, Julie Foucquier, Michael W. Sereda, Daniel Cohen, Nathalie Cholet, Klaus-Armin Nave, Aurélie Boucard, Rodolphe Hajj, Viviane Bertrand

Publikováno v: Orphanet Journal of Rare Diseases

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of peripheral myelination, loss of long axons, and progressive impairment th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93103b85734e265012438f4aaacfa7ed
http://europepmc.org/articles/PMC4279797

Transcripts of the genes sacB, amyE, sacC and csn expressed in Bacillus subtilis under the control of the 5′ untranslated sacR region display different stabilities that can be modulated

Autor: Régis Chambert, Laurence Leloup, Jean-Pierre Daguer, Yannick Pereira, Marie-Françoise Petit-Glatron

Publikováno v: Microbiology. 147:1331-1341

When Bacillus subtilis levanase (SacC), alpha-amylase (AmyE) and chitosanase (Csn) structural genes were expressed under the regulated control of sacR, the inducible levansucrase (SacB) leader region in a degU32(Hy) mutant, it was observed that the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33963dcbb934f6592427913024e0bdbd
https://doi.org/10.1099/00221287-147-5-1331

Combined proteome and metabolite-profiling analyses reveal surprising insights into yeast sulfur metabolism

Autor: Christophe Junot, Jean Labarre, Jean-Claude Tabet, Eric Ezan, Alexandra Lafaye, Yannick Pereira, Gilles Lagniel

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280, pp.24723-24730
Journal of Biological Chemistry, 2005, 280, pp.24723-24730

Metabolomics is considered as an emerging new tool for functional proteomics in the identification of new protein function or in projects aiming at modeling whole cell metabolism. When combined with proteome studies, metabolite-profiling analyses rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e11e3d8005154e050bad56ed1cca0d3
https://pubmed.ncbi.nlm.nih.gov/15855158

Intimate adhesion of Neisseria meningitidis to human epithelial cells is under the control of the crgA gene, a novel LysR-type transcriptional regulator

Autor: Ala-Eddine Deghmane, Mireille Larribe, Dario Giorgini, Muhamed-Kheir Taha, Stéphanie Petit, Yannick Pereira, Andrzej Topilko

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2000, 19 (5), pp.1068-1078. ⟨10.1093/emboj/19.5.1068⟩
EMBO Journal, 2000, 19 (5), pp.1068-1078. ⟨10.1093/emboj/19.5.1068⟩

International audience; PilC1, a pilus-associated protein in Neisseria menin- gitidis, is a key element in initial meningococcal adhesion to target cells. A promoter element (CREN, contact regulatory element of Neisseria) is responsible for the trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adc01883c24825f13fe6d8e0e9d706a
https://hal-pasteur.archives-ouvertes.fr/pasteur-03262268

Chromate Causes Sulfur Starvation in Yeast.

Autor: Yannick Pereira, Gilles Lagniel, Emmanuel Godat, Peggy Baudouin-Cornu, Christophe Junot, Jean Labarre

Publikováno v: Toxicological Sciences; Dec2008, Vol. 106 Issue 2, p400-400, 1p