Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yannick P. Kok"'
Autor:
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel vanVugt, Libor Macurek
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 6-20 (2024)
Oncogene‐induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common cause of replication stress in various cancers.
Externí odkaz:
https://doaj.org/article/bca8c70888bf4c5eb9181c8b76ab63bf
Autor:
Anastasia Audrey, Yannick P. Kok, Shibo Yu, Lauren de Haan, Bert van de Kooij, Nathalie van den Tempel, Mengting Chen, H. Rudolf de Boer, Bert van der Vegt, Marcel A.T.M. van Vugt
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114116- (2024)
Summary: Overexpression of Cyclin E1 perturbs DNA replication, resulting in DNA lesions and genomic instability. Consequently, Cyclin E1-overexpressing cancer cells increasingly rely on DNA repair, including RAD52-mediated break-induced replication d
Externí odkaz:
https://doaj.org/article/86d70d48e7bc40ab910f579a37c6c2d3
Autor:
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
Externí odkaz:
https://doaj.org/article/6a7ed7595d2b4f12a042a1aaa930abc6
Autor:
Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/f0f9f42a292e496a8dbe120dc4b20697
Autor:
Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. vanVugt
Publikováno v:
Molecular Oncology, Vol 13, Iss 11, Pp 2422-2440 (2019)
Poly(ADP‐ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR‐deficient tumors efficiently respond to PARP inhibition an
Externí odkaz:
https://doaj.org/article/6e02b44132fe453cb49c7cb621010ed2
Autor:
Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2345-2357.e5 (2019)
Summary: Triple-negative breast cancers (TNBCs) display great diversity in cisplatin sensitivity that cannot be explained solely by cancer-associated DNA repair defects. Differential activation of the DNA damage response (DDR) to cisplatin has been p
Externí odkaz:
https://doaj.org/article/73807b01c48f4497b009cc2ba8efa297
Autor:
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Publikováno v:
Molecular Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::002d0e2bea494925e239a3b44e2c2e34
https://doi.org/10.1002/1878-0261.13433
https://doi.org/10.1002/1878-0261.13433
Autor:
null Andra S. Martinikova, null Miroslav Stoyanov, null Anna Oravetzova, null Yannick P. Kok, null Shibo Yu, null Jana Dobrovolna, null Pavel Janscak, null Marcel van Vugt, null Libor Macurek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ad7a32bff781c99611837832fa513d
https://doi.org/10.1002/1878-0261.13433/v2/response1
https://doi.org/10.1002/1878-0261.13433/v2/response1
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z
Autor:
Arkajyoti Bhattacharya, Marieke Everts, Sergi Guerrero Llobet, Rudolf S N Fehrmann, Pepijn M Schoonen, Marcel A. T. M. van Vugt, Nathalie van den Tempel, Yannick P Kok
Publikováno v:
Oncogenesis, Vol 9, Iss 10, Pp 1-15 (2020)
Oncogenesis, 9(10):88. Nature Publishing Group
Oncogenesis
Oncogenesis, 9(10):88. Nature Publishing Group
Oncogenesis
Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high levels of replication stress, tumors depend on pathways to deal with these DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a3cca2f6a1dedeee0c223671bd90ed
http://link.springer.com/article/10.1038/s41389-020-00270-2
http://link.springer.com/article/10.1038/s41389-020-00270-2