Výsledky vyhledávání - "Yannick Morias"

Akademický článek

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Autor: Veronika Voronova, Victor Sokolov, Yannick Morias, Malin Jonsson Boezelman, Maria Wågberg, Marcus Henricsson, Karl Hansson, Alexey Goltsov, Kirill Peskov, Monika Sundqvist

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to

Externí odkaz: https://doaj.org/article/c4ffbcea717249be8d4a464543d8c06f

Zobrazit plný text záznamu

Akademický článek

The regulatory role of PGC1α‐related coactivator in response to drug‐induced liver injury

Autor: Marcin Buler, Thomas Naessens, Johan Mattsson, Yannick Morias, Magnus Söderberg, Philip Robbins, Lillevi Kärrberg, Tor S. Svensson, Petra Thulin, Björn Glinghammar, Richard C. Scarpulla, Ulf Andersson

Publikováno v: FASEB BioAdvances, Vol 2, Iss 8, Pp 453-463 (2020)

Abstract PGC1α‐Related Coactivator (PRC) is a transcriptional coactivator promoting cytokine expression in vitro in response to mitochondrial injury and oxidative stress, however, its physiological role has remained elusive. Herein we investigate

Externí odkaz: https://doaj.org/article/4bb78bbb3c9140b390f78458ff91618b

Zobrazit plný text záznamu

Akademický článek

Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

Autor: Gilles Vanwalleghem, Yannick Morias, Alain Beschin, David E. Szymkowski, Etienne Pays

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract Infection of C57Bl/6 mice by pleomorphic African trypanosomes Trypanosoma brucei and T. congolense is characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to control T. brucei growt

Externí odkaz: https://doaj.org/article/9ccb1178e6e74b48a7a7e05f9c0d3d11

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Autor: Damya Laoui, Jiri Keirsse, Yannick Morias, Eva Van Overmeire, Xenia Geeraerts, Yvon Elkrim, Mate Kiss, Evangelia Bolli, Qods Lahmar, Dorine Sichien, Jens Serneels, Charlotte L. Scott, Louis Boon, Patrick De Baetselier, Massimiliano Mazzone, Martin Guilliams, Jo A. Van Ginderachter

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)

Dendritic cells are antigen-presenting cells consisting of distinct subsets originating from different lineages. Here, the authors identify the subsets of dendritic cells populating the tumour tissue in both mice and humans and find they have opposin

Externí odkaz: https://doaj.org/article/a203b2adbb4344c7be80bcf4c68f425a

Zobrazit plný text záznamu

Akademický článek

Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages.

Autor: Yannick Morias, Chloé Abels, Damya Laoui, Eva Van Overmeire, Martin Guilliams, Elio Schouppe, Frank Tacke, Carlie J deVries, Patrick De Baetselier, Alain Beschin

Publikováno v: PLoS Pathogens, Vol 11, Iss 5, p e1004873 (2015)

Monocytes consist of two well-defined subsets, the Ly6C+ and Ly6C- monocytes. Both CD11b+ myeloid cells populations have been proposed to infiltrate tissues during inflammation. While infiltration of Ly6C+ monocytes is an established pathogenic facto

Externí odkaz: https://doaj.org/article/364b51ac1b5243528b50d1fa55f4e8c0

Zobrazit plný text záznamu

Akademický článek

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003731 (2013)

In order to promote infection, the blood-borne parasite Trypanosoma brucei releases factors that upregulate arginase expression and activity in myeloid cells.By screening a cDNA library of T. brucei with an antibody neutralizing the arginase-inducing

Externí odkaz: https://doaj.org/article/511927836da54f7db78eab97bcc2f4c0

Zobrazit plný text záznamu

Akademický článek

Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling.

Autor: Tom Bosschaerts, Martin Guilliams, Benoît Stijlemans, Yannick Morias, Daniel Engel, Frank Tacke, Michel Hérin, Patrick De Baetselier, Alain Beschin

Publikováno v: PLoS Pathogens, Vol 6, Iss 8, p e1001045 (2010)

The development of classically activated monocytic cells (M1) is a prerequisite for effective elimination of parasites, including African trypanosomes. However, persistent activation of M1 that produce pathogenic molecules such as TNF and NO contribu

Externí odkaz: https://doaj.org/article/ad370310b4964e4b9f754ad86a049f27

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání