The Chemically Inducible Plant Cytochrome P450 CYP76B1 Actively Metabolizes Phenylureas and Other Xenobiotics

Autor: Monique LeRet, Danièle Werck-Reichhart, Svetlana Nedelkina, Francisco Cabello-Hurtado, Luc Didierjean, O. Sorokine, Yannick Batard, Tiburce Robineau

Publikováno v: Plant Physiology. 118:1049-1056

Cytochrome P450s (P450s) constitute one of the major classes of enzymes that are responsible for detoxification of exogenous molecules both in animals and plants. On the basis of its inducibility by exogenous chemicals, we recently isolated a new pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8e18e4dfc3aca69bd447d865c949de0
https://doi.org/10.1104/pp.118.3.1049

Catalytic Properties of the Plant Cytochrome P450 CYP73 Expressed in Yeast. Substrate Specificity of a Cinnamate Hydroxylase

Autor: Francis Durst, Claudia Mignotte-Vieux, Yannick Batard, Danièle Werck-Reichhart, Marie Agnès Pierrel, Michael Kazmaier

Publikováno v: European Journal of Biochemistry. 224:835-844

The catalytic properties of CYP73, a cinnamate 4-hydroxylase isolated from Helianthus tuberosus tuber [Teutsch, H. G., Hasenfratz, M. P., Lesot, A., Stoltz, C., Garnier, J. M., Jeltsch, J. M., Durst, F. & Werck-Reichhart, D. (1993) Proc. Natl Acad. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7fc17c12d2ebd8f3186a7c14963922
https://doi.org/10.1111/j.1432-1033.1994.00835.x

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans

Autor: Volker Fischer, Phi Tran, Dan Howard, Handan He, Yannick Batard, James B. Mangold, Helen Gu, Harold Smith, Lai Wang, Hequn Yin, Heidi J. Einolf

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 37(3)

The absorption, metabolism, and excretion of (1-[[3-hydroxy-1-adamantyl) amino] acetyl]-2-cyano-( S )-pyrrolidine (vildagliptin), an orally active and highly selective dipeptidyl peptidase 4 inhibitor developed for the treatment of type 2 diabetes, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05005a34529b237405389e332ab1fc63
https://pubmed.ncbi.nlm.nih.gov/19074975

Increasing Expression of P450 and P450-Reductase Proteins from Monocots in Heterologous Systems

Autor: Yannick Batard, Svetlana Nedelkina, Hubert Schaller, Alain Hehn, Michel Schalk, Ken Pallett, Danièle Werck-Reichhart

Publikováno v: Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2000, 379 (1), pp.161-169. ⟨10.1006/abbi.2000.1867⟩

International audience; Monocotyledonous crop plants are usually more resistant to herbicides than grass weeds and most dicots. Their resistance to herbicides is mediated in many cases by P450 oxygenases. Monocots thus constitute an appealing source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdc945a91e7085d6ede6c0a3a5ac5f4
https://hal.archives-ouvertes.fr/hal-01738306

Molecular cloning and functional expression in yeast of CYP76B1, a xenobiotic-inducible 7-ethoxycoumarin O-de-ethylase from Helianthus tuberosus

Autor: Danièle Werck-Reichhart, Michel Schalk, Francis Durst, Monique LeRet, Tiburce Robineau, Yannick Batard

Publikováno v: The Plant journal : for cell and molecular biology. 14(1)

Summary In order to obtain plant markers of chemical stress and possible tools for the bio-monitoring of pollution, a protein purification/PCR approach was used to isolate cDNAs of xenobiotic-inducible P450 oxygenases. O-dealkylation of 7-ethoxycouma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d56b0e9deca0cfb8477e69da35e6368
https://pubmed.ncbi.nlm.nih.gov/9681028