Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation

Autor: Juliette Ezpeleta, Vincent Baudouin, Zaira E. Arellano-Anaya, François Boudet-Devaud, Mathéa Pietri, Anne Baudry, Anne-Marie Haeberlé, Yannick Bailly, Odile Kellermann, Jean-Marie Launay, Benoit Schneider

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Aβ plaques have been detected in brains of patients with prion diseases. Here, using mice, the authors show that prion infection enhances Aβ production via a PDK1-TACE mechanism and that brain deposition of Aβ induced by Aβ seeds co-transmitted w

Externí odkaz: https://doaj.org/article/1e4e707388e247a5aac2217f5c04838e

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.

Autor: Aurélie Alleaume-Butaux, Simon Nicot, Mathéa Pietri, Anne Baudry, Caroline Dakowski, Philippe Tixador, Hector Ardila-Osorio, Anne-Marie Haeberlé, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneider

Publikováno v: PLoS Pathogens, Vol 11, Iss 8, p e1005073 (2015)

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil

Externí odkaz: https://doaj.org/article/f1c7ab37f8994140b4f83ce0e621baa2

Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling

Autor: Luiz W. Ribeiro, Mathéa Pietri, Hector Ardila-Osorio, Anne Baudry, François Boudet-Devaud, Chloé Bizingre, Zaira E. Arellano-Anaya, Anne-Marie Haeberlé, Nicolas Gadot, Sonja Boland, Stéphanie Devineau, Yannick Bailly, Odile Kellermann, Anna Bencsik, Benoit Schneider

Publikováno v: Particle and Fibre Toxicology
Particle and Fibre Toxicology, 2022, 19 (1), pp.48. ⟨10.1186/s12989-022-00490-x⟩
Particle and Fibre Toxicology, BioMed Central, 2022, 19 (1), pp.48. ⟨10.1186/s12989-022-00490-x⟩

Background Epidemiological emerging evidence shows that human exposure to some nanosized materials present in the environment would contribute to the onset and/or progression of Alzheimer’s disease (AD). The cellular and molecular mechanisms whereb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8700657a49a8e807d7cdd2e750dbdffd
https://pubmed.ncbi.nlm.nih.gov/35840975

Spectroscopic, pressure and temperature measurements of the reactant mixing process in sodium-water reaction

Autor: David Ramel, Alexandre Allou, Yannick Bailly, François Beauchamp, Lucas David, Mirjana Milanovic, Philippe Hervé

Publikováno v: Nuclear Engineering and Design
Nuclear Engineering and Design, 2020, 364, pp.110638 (9)
Nuclear Engineering and Design, Elsevier, 2020, 364, pp.110638. ⟨10.1016/j.nucengdes.2020.110638⟩
Nuclear Engineering and Design, 2020, 364, pp.110638. ⟨10.1016/j.nucengdes.2020.110638⟩

International audience; The reaction of sodium metal with liquid water is a heterogeneous, exothermic reaction known to be prone to runaway with explosive effects when uncontrolled. The occurrence of runaways requires the reactants to be effectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27cadf9201ee906ec2dcbc98624157
https://hal.archives-ouvertes.fr/hal-02993862

Cerebellar compartmentation of prion pathogenesis

Autor: François Boudet-Devaud, Vincent Béringue, Anne-Marie Haeberlé, Yannick Bailly, Catherine Vidal, Valérie Demais, Aurélie Guillemain, Stanislas Demuth, Nancy J. Grant, Juliette Ezpeleta, Odile Kellermann, Benoit Schneider, Audrey Ragagnin

Publikováno v: Brain Pathology. 28:240-263

In prion diseases, the brain lesion profile is influenced by the prion "strain" properties, the invasion route to the brain, and still unknown host cell-specific parameters. To gain insight into those endogenous factors, we analyzed the histopatholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b199e078b1258483ec874e732d5d4936
https://doi.org/10.1111/bpa.12503