Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Yannick, Schreiber"'
Autor:
Jörn Lötsch, Khayal Gasimli, Sebastian Malkusch, Lisa Hahnefeld, Carlo Angioni, Yannick Schreiber, Sandra Trautmann, Saskia Wedel, Dominique Thomas, Nerea Ferreiros Bouzas, Christian H Brandts, Benjamin Schnappauf, Christine Solbach, Gerd Geisslinger, Marco Sisignano
Publikováno v:
eLife, Vol 13 (2024)
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify th
Externí odkaz:
https://doaj.org/article/2f70ecc6b60c49e0aa4c7ee6c353f55a
Autor:
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-21 (2023)
Abstract Background Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current treatment possibilitie
Externí odkaz:
https://doaj.org/article/7393b95fee1a48c09212292b2adeaadf
Autor:
Tamara Rothenburger, Dominique Thomas, Yannick Schreiber, Paul R. Wratil, Tamara Pflantz, Kirsten Knecht, Katie Digianantonio, Joshua Temple, Constanze Schneider, Hanna-Mari Baldauf, Katie-May McLaughlin, Florian Rothweiler, Berna Bilen, Samira Farmand, Denisa Bojkova, Rui Costa, Nerea Ferreirós, Gerd Geisslinger, Thomas Oellerich, Yong Xiong, Oliver T. Keppler, Mark N. Wass, Martin Michaelis, Jindrich Cinatl
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)
Abstract Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMH
Externí odkaz:
https://doaj.org/article/d96327060ccf4b409f6c8453b5c904c2
Autor:
Peter Rappl, Silvia Rösser, Patrick Maul, Rebekka Bauer, Arnaud Huard, Yannick Schreiber, Dominique Thomas, Gerd Geisslinger, Per-Johan Jakobsson, Andreas Weigert, Bernhard Brüne, Tobias Schmid
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-10 (2021)
Abstract Despite the progress to understand inflammatory reactions, mechanisms causing their resolution remain poorly understood. Prostanoids, especially prostaglandin E2 (PGE2), are well-characterized mediators of inflammation. PGE2 is produced in a
Externí odkaz:
https://doaj.org/article/82e45cbb0c5e4c0696246dff61defdd3
Autor:
Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C. J. Hofmann, Nina Pannwitz, Eduard Resch, Sonja Luckhardt, Ann-Kathrin Schneider, Sandra Trautmann, Yannick Schreiber, Robert Gurke, Michael J. Parnham, Uwe Till, Gerd Geisslinger
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
A causal contribution of hyperhomocysteinemia to cognitive decline and Alzheimer’s disease (AD), as well as potential prevention or mitigation of the pathology by dietary intervention, have frequently been subjects of controversy. In the present in
Externí odkaz:
https://doaj.org/article/5aafda3fb0b74237ad0cd5b0b0337cc4
Autor:
Vera Khodzhaeva, Yannick Schreiber, Gerd Geisslinger, Ralf P. Brandes, Bernhard Brüne, Dmitry Namgaladze
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria. Here, we explored how MFN2 influences mitochondrial functions and inflammato
Externí odkaz:
https://doaj.org/article/b46e44135c894a1d84fafbff01de9537
Autor:
Susanne Schiffmann, Sandra Gunne, Thomas Ulshöfer, Marina Henke, Luise A. Roser, Ann-Kathrin Schneider, Jindrich Cinatl, Dominique Thomas, Yannick Schreiber, Pia Viktoria Wagner, Arnold Grünweller, Michael J. Parnham
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1086 (2022)
We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC50 value of about 5 nM. The cytotoxic profile of silvestrol was assessed in vari
Externí odkaz:
https://doaj.org/article/b619ea0c7826480faf8049ba991d8de3
Autor:
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolis
Externí odkaz:
https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34
Autor:
Nathalie Brunkhorst-Kanaan, Sandra Trautmann, Yannick Schreiber, Dominique Thomas, Sarah Kittel-Schneider, Robert Gurke, Gerd Geisslinger, Andreas Reif, Irmgard Tegeder
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1173 (2021)
Genes encoding endocannabinoid and sphingolipid metabolism pathways were suggested to contribute to the genetic risk towards attention deficit hyperactivity disorder (ADHD). The present pilot study assessed plasma concentrations of candidate endocann
Externí odkaz:
https://doaj.org/article/3347387d05d044cb907faff9e33e58e1
Autor:
Thomas Bärnthaler, Jovana Maric, Wolfgang Platzer, Viktoria Konya, Anna Theiler, Carina Hasenöhrl, Benjamin Gottschalk, Sandra Trautmann, Yannick Schreiber, Wolfgang F. Graier, Rudolf Schicho, Gunther Marsche, Andrea Olschewski, Dominique Thomas, Rufina Schuligoi, Akos Heinemann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Disruption of the blood-air barrier, which is formed by lung microvascular endothelial and alveolar epithelial cells, is a hallmark of acute lung injury. It was shown that alveolar epithelial cells release an unidentified soluble factor that
Externí odkaz:
https://doaj.org/article/5954ae3d0f3245918a8d9c82f4b24f8b