Ursodeoxycholic Acid for Trans Intestinal Cholesterol Excretion Stimulation: A Randomized Placebo Controlled Crossover Study

Autor: Reindert F. Oostveen, Yannick Kaiser, Merel L. Hartgers, Emma C. E. Meessen, Aldo Grefhorst, G. Kees Hovingh, Folkert Kuipers, Erik S. G. Stroes, Albert K. Groen, Laurens F. Reeskamp

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)

Background The trans intestinal cholesterol excretion (TICE) pathway is a potential therapeutic target to reduce plasma low‐density lipoprotein (LDL) cholesterol levels. TICE encompasses the direct excretion of cholesterol by enterocytes into feces

Externí odkaz: https://doaj.org/article/657e0bd088834806b65aaaa0e889e79d

Atorvastatin treatment does not abolish inflammatory mediated cardiovascular risk in subjects with chronic kidney disease

Autor: Renate M. Hoogeveen, Simone L. Verweij, Yannick Kaiser, Jeffrey Kroon, Hein J. Verberne, Liffert Vogt, Sophie J. Bernelot Moens, Erik S. G. Stroes

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

Abstract Individuals with chronic kidney disease are at an increased risk for cardiovascular disease. This risk may partially be explained by a chronic inflammatory state in these patients, reflected by increased arterial wall and cellular inflammati

Externí odkaz: https://doaj.org/article/5c18abc477fa4ebbbdfb11d89e5dbb97

Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification

Autor: Yannick Kaiser, Janine E van der Toorn, Sunny S Singh, Kang H Zheng, Maryam Kavousi, Eric J G Sijbrands, Erik S G Stroes, Meike W Vernooij, Yolanda B de Rijke, S Matthijs Boekholdt, Daniel Bos

Publikováno v: European heart journal, 43(39), 3960-3967. Oxford University Press
European Heart Journal, 43(39), 3960-3967. Oxford University Press

Aim Lipoprotein(a) [Lp(a)] is a potential causal factor in the pathogenesis of aortic valve disease. However, the relationship of Lp(a) with new onset and progression of aortic valve calcium (AVC) has not been studied. The purpose of the study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31458618b1a616807d51b9f9e7d26e36
https://doi.org/10.1093/eurheartj/ehac377

Lipoprotein(a), venous thromboembolism and COVID-19

Autor: Nick S. Nurmohamed, Didier Collard, Laurens F. Reeskamp, Yannick Kaiser, Jeffrey Kroon, Tycho R. Tromp, Bert-Jan H. van den Born, Michiel Coppens, Alexander P.J. Vlaar, Martijn Beudel, Diederik van de Beek, Nick van Es, Patrick M. Moriarty, Sotirios Tsimikas, Erik S.G. Stroes

Publikováno v: Amsterdam UMC Covid-19 Biobank 2022, ' Lipoprotein(a), venous thromboembolism and COVID-19 : A pilot study ', Atherosclerosis, vol. 341, pp. 43-49 . https://doi.org/10.1016/j.atherosclerosis.2021.12.008
Atherosclerosis, 341, 43-49. Elsevier Ireland Ltd
Atherosclerosis

Background and aims Thrombosis is a major driver of adverse outcome and mortality in patients with Coronavirus disease 2019 (COVID-19). Hypercoagulability may be related to the cytokine storm associated with COVID-19, which is mainly driven by interl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d32fdedaef6fdb1129164b8dc1cd06
https://doi.org/10.1016/j.atherosclerosis.2021.12.008

Serum Lipoprotein(a) and Bioprosthetic Aortic Valve Degeneration

Autor: Simona B Botezatu, Evangelos Tzolos, Yannick Kaiser, Timothy R G Cartlidge, Jacek Kwiecinski, Anna K Barton, Xinming Yu, Michelle C Williams, Edwin J R van Beek, Audrey White, Jeffrey Kroon, Piotr J Slomka, Bogdan A Popescu, David E Newby, Erik S G Stroes, Kang H Zheng, Marc R Dweck

Publikováno v: Botezatu, S B, Tzolos, E, Kaiser, Y, Cartlidge, T R G, Kwiecinski, J, Barton, A, Yu, X, Williams, M C, van Beek, E J R, White, A, Kroon, J, Slomka, P J, Popescu, B A, Newby, D E, Stroes, E S G, Zheng, K H & Dweck, M R 2023, ' Serum Lipoprotein(a) and Bioprosthetic Aortic Valve Degeneration ', European Heart Journal-Cardiovascular Imaging . https://doi.org/10.1093/ehjci/jeac274
European heart journal. Cardiovascular Imaging, 24(6), 759-767. Oxford University Press

Aims Bioprosthetic aortic valve degeneration demonstrates pathological similarities to aortic stenosis. Lipoprotein(a) [Lp(a)] is a well-recognized risk factor for incident aortic stenosis and disease progression. The aim of this study is to investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e23eb6357d3caf553faffe685f73
https://www.pure.ed.ac.uk/ws/files/318016259/Supplementary_Material_online_final.docx