Low-Frequency Raman Spectroscopy: An Exceptional Tool for Exploring Metastability Driven States Induced by Dehydration

Autor: Yannick Guinet, Laurent Paccou, Alain Hédoux

Publikováno v: Pharmaceutics, Vol 15, Iss 7, p 1955 (2023)

The use of low-frequency Raman spectroscopy (LFRS; ω < 150 cm−1) is booming in the pharmaceutical industry. Specific processing of spectra is required to use the wealth of information contained in this spectral region. Spectra processing and the u

Externí odkaz: https://doaj.org/article/ea3acf506e2247bebbc7c9e08844adf1

Analysis of Co-Crystallization Mechanism of Theophylline and Citric Acid from Raman Investigations in Pseudo Polymorphic Forms Obtained by Different Synthesis Methods

Autor: Yannick Guinet, Laurent Paccou, Alain Hédoux

Publikováno v: Molecules, Vol 28, Iss 4, p 1605 (2023)

Designing co-crystals can be considered as a commonly used strategy to improve the bioavailability of many low molecular weight drug candidates. The present study has revealed the existence of three pseudo polymorphic forms of theophylline–citric a

Externí odkaz: https://doaj.org/article/1a211107aa1046d295e587185fc5490c

Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for Obtaining Tunable Customized Drug Delivery

Autor: Basma Moutamenni, Nicolas Tabary, Alexandre Mussi, Jeremy Dhainaut, Carmen Ciotonea, Alexandre Fadel, Laurent Paccou, Jean-Philippe Dacquin, Yannick Guinet, Alain Hédoux

Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 390 (2023)

Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted

Externí odkaz: https://doaj.org/article/7ebfa63f52a64b73a905e98885c7b421

Identification of incommensurability in l-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids?

Autor: Yannick Guinet, Laurent Paccou, Florence Danède, Patrick Derollez, Alain Hédoux

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, 2022, Physical Chemistry Chemical Physics, 24 (44), pp.27023-27030. ⟨10.1039/d2cp00989g⟩

International audience; L-Leucine is an essential amino acid which has been focusing a lot of investigations on its phase transition sequence for more than fifty years. Combining Raman spectroscopy and X-ray diffraction experiments provides a new int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e808fe6546cfd602e95265628fac5d11
https://doi.org/10.1039/d2cp00989g

Revisiting the phase transition sequence in L-methionine: Description of the disordering mechanism in an essential amino acid

Autor: Yannick Guinet, Laurent Paccou, Florence Danède, Alain Hédoux

Publikováno v: Journal of Chemical Physics
Journal of Chemical Physics, 2022, Journal of Chemical Physics, 156 (3), pp.034501. ⟨10.1063/5.0077743⟩

International audience; Raman spectroscopy investigations on L-methionine (L-Met) performed in large temperature range (170 K – 420 K) and in a wide spectral window (5 – 3600 cm-1) have revealed an extended disordering mechanism triggered by ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f9d6fda92dcf90abccebf5a68c6255
https://pubmed.ncbi.nlm.nih.gov/35065577