Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yannic Alber"'
Autor:
Jana Fassunke, Fabienne Müller, Marina Keul, Sebastian Michels, Marcel A. Dammert, Anna Schmitt, Dennis Plenker, Jonas Lategahn, Carina Heydt, Johannes Brägelmann, Hannah L. Tumbrink, Yannic Alber, Sebastian Klein, Alena Heimsoeth, Ilona Dahmen, Rieke N. Fischer, Matthias Scheffler, Michaela A. Ihle, Vanessa Priesner, Andreas H. Scheel, Svenja Wagener, Anna Kron, Konrad Frank, Katia Garbert, Thorsten Persigehl, Michael Püsken, Stefan Haneder, Bernhard Schaaf, Ernst Rodermann, Walburga Engel-Riedel, Enriqueta Felip, Egbert F. Smit, Sabine Merkelbach-Bruse, H. Christian Reinhardt, Stefan M. Kast, Jürgen Wolf, Daniel Rauh, Reinhard Büttner, Martin L. Sos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase rem
Externí odkaz:
https://doaj.org/article/d0509a8e9f1241e6a692b9bd9e5d0a9b
Autor:
Mark D. Tully, Hans Kiefer, Yuguo Zang, Patrick Garidel, Martin Westermann, Lars V. Schäfer, Alexander Kuhn, Yannic Alber, Hendrik Göddeke, Stefan M. Kast, Michaela Blech, Sebastian Kube, Stefan Hörer
Publikováno v:
Biophys J
We report the x-ray crystal structure of intact, full-length human immunoglobulin (IgG4) at 1.8 A resolution. The data for IgG4 (S228P), an antibody targeting the natriuretic peptide receptor A, show a previously unrecognized type of Fab-Fc orientati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8361f7ccfc2c35270f79a642cc3a04
https://doi.org/10.1016/j.bpj.2019.03.036
https://doi.org/10.1016/j.bpj.2019.03.036
Autor:
Katia Garbert, Michaela Angelika Ihle, Ilona Dahmen, Dennis Plenker, Svenja Wagener, Stefan Haneder, Vanessa Priesner, Rieke Fischer, Jana Fassunke, Reinhard Büttner, Hannah L. Tumbrink, Marcel A. Dammert, Anna Kron, Yannic Alber, Johannes Brägelmann, Walburga Engel-Riedel, Sebastian Klein, Daniel Rauh, Martin L. Sos, Marina Keul, Konrad Frank, Alena Heimsoeth, Thorsten Persigehl, Stefan M. Kast, Michael Püsken, Enriqueta Felip, H. Christian Reinhardt, Sabine Merkelbach-Bruse, Fabienne Müller, Sebastian Michels, Jürgen Wolf, Carina Heydt, Egbert F. Smit, Anna Schmitt, Bernhard Schaaf, Matthias Scheffler, Andreas H. Scheel, Ernst Rodermann, Jonas Lategahn
Publikováno v:
Nature Communications, 9(1). Nature Publishing Group UK
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Fassunke, J, Müller, F, Keul, M, Michels, S, Dammert, M A, Schmitt, A, Plenker, D, Lategahn, J, Heydt, C, Brägelmann, J, Tumbrink, H L, Alber, Y, Klein, S, Heimsoeth, A, Dahmen, I, Fischer, R N, Scheffler, M, Ihle, M A, Priesner, V, Scheel, A H, Wagener, S, Kron, A, Frank, K, Garbert, K, Persigehl, T, Püsken, M, Haneder, S, Schaaf, B, Rodermann, E, Engel-Riedel, W, Felip, E, Smit, E F, Merkelbach-Bruse, S, Reinhardt, H C, Kast, S M, Wolf, J, Rauh, D, Büttner, R & Sos, M L 2018, ' Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors ', Nature Communications, vol. 9, no. 1, pp. 4655 . https://doi.org/10.1038/s41467-018-07078-0
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Fassunke, J, Müller, F, Keul, M, Michels, S, Dammert, M A, Schmitt, A, Plenker, D, Lategahn, J, Heydt, C, Brägelmann, J, Tumbrink, H L, Alber, Y, Klein, S, Heimsoeth, A, Dahmen, I, Fischer, R N, Scheffler, M, Ihle, M A, Priesner, V, Scheel, A H, Wagener, S, Kron, A, Frank, K, Garbert, K, Persigehl, T, Püsken, M, Haneder, S, Schaaf, B, Rodermann, E, Engel-Riedel, W, Felip, E, Smit, E F, Merkelbach-Bruse, S, Reinhardt, H C, Kast, S M, Wolf, J, Rauh, D, Büttner, R & Sos, M L 2018, ' Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors ', Nature Communications, vol. 9, no. 1, pp. 4655 . https://doi.org/10.1038/s41467-018-07078-0
The emergence of acquired resistance against targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. In a subgroup of these patients we identified an association between selection of EGFRT790M-negative but EGFRG724S-positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b61f1197102aefb2df6be0cd940b1e
https://research.vumc.nl/en/publications/2fd9ae51-e255-44f7-bf6f-197f89e0a268
https://research.vumc.nl/en/publications/2fd9ae51-e255-44f7-bf6f-197f89e0a268
Autor:
Neil Q. McDonald, Kris Gevaert, Dennis Plenker, René P. Zahedi, Georg Pall, Mike Bührmann, Johannes M. Heuckmann, Reinhard Buettner, Marcel A. Dammert, Daniel Schütte, Phillip P. Knowles, Maarten Aerts, Carina Lorenz, Andreas H. Scheel, Verena Tischler, Joachim Diebold, Justina Stark, Martin L. Sos, Oliver Gautschi, Julian Engel, Florian Mrugalla, Rakhee Chauhan, Johannes Brägelmann, Frauke Leenders, Yannic Alber, Stefan M. Kast, Oliver Pagel, Martin Peifer, Maximilian Riedel, Marina Keul, Kevan M. Shokat, André Richters, Jürgen Wolf, Yanrui Song, Roman K. Thomas
Publikováno v:
Science Translational Medicine. 9
Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide further evidence that current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c142beb8efcb3a7ac25f3d7cd21bc6
https://doi.org/10.1126/scitranslmed.aah6144
https://doi.org/10.1126/scitranslmed.aah6144