Výsledky vyhledávání

Akademický článek

Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation

Autor: Yannan Yan, Mark Alexander Skarsfeldt, Jonas Goldin Diness, Bo Hjorth Bentzen

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100898- (2021)

Background: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion c

Externí odkaz: https://doaj.org/article/82411e8ecce4417c847b406d7fefec9e

Zobrazit plný text záznamu

Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of k18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2

Autor: Gary Ewart, Michael Bobardt, Bo Hjorth Bentzen, Yannan Yan, Audrey Thomson, Klaus Klumpp, Stephen Becker, Mette M. Rosenkilde, Michelle Miller, Philippe Gallay

The Coronavirus envelope (E) protein is a small structural protein with ion channel activity that plays an important role in virus assembly, budding, immunopathogenesis and disease severity. The viroporin E is also located in Golgi and ER membranes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::813ca030c98b2651f3d9953b25c26d1d
https://doi.org/10.1101/2023.03.29.534854

Zobrazit plný text záznamu

Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events

Autor: Benedikt Linz, Eva M. Hesselkilde, Mark A. Skarsfeldt, Julie N. Hertel, Stefan M. Sattler, Yannan Yan, Jacob Tfelt‐Hansen, Jonas G. Diness, Bo H. Bentzen, Dominik Linz, Thomas Jespersen

Publikováno v: Linz, B, Hesselkilde, E M, Skarsfeldt, M A, Hertel, J N, Sattler, S M, Yan, Y, Tfelt-Hansen, J, Diness, J G, Bentzen, B H, Linz, D & Jespersen, T 2023, ' Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events ', Journal of Cardiovascular Electrophysiology, vol. 34, no. 1, pp. 126-134 . https://doi.org/10.1111/jce.15769
Journal of Cardiovascular Electrophysiology, 34(1), 126-134. Wiley

BACKGROUND: Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available pharmacological interventions. We investigated atrial antiarrhythmogenic properties and ventricular e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ba9b6efcb8475d708a12d2946d4001
https://pubmed.ncbi.nlm.nih.gov/36482155

Zobrazit plný text záznamu

Akademický článek

Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization

Autor: Yang Jin, Chuan Hu, Jiechao Xia, Dingqi Xie, Lin Ye, Xinyi Ye, Li Jiang, Honghai Song, Yutao Zhu, Sicheng Jiang, Weiqing Li, Weiming Qi, Yannan Yang, Zhijun Hu

Publikováno v: Bioactive Materials, Vol 42, Iss , Pp 613-627 (2024)

Clusterzymes are synthetic enzymes exhibiting substantial catalytic activity and selectivity, which are uniquely driven by single-atom constructs. A dramatic increase in antioxidant capacity, 158 times more than natural trolox, is noted when single-a

Externí odkaz: https://doaj.org/article/4d1ad7d4e19e4b4888c1d4aa08dae15a

Zobrazit plný text záznamu

Process optimization of neodymium chloride solutions precipitated by magnesium bicarbonate

Autor: Xiaowei Huang, Zongyu Feng, Liangshi Wang, Yihanna Hu, Kai Li, Yannan Yan, Yang Xu, Yongke Hou

Publikováno v: Journal of Rare Earths. 37:437-442

Rare earths (REs) are of vital importance for the development of new materials and green energy. Magnesium bicarbonate is one of the most recyclable and environmental-friendly precipitant for REs recovery from leaching solutions. Nd2(CO3)3 has diffic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4ef3294f31d6c789027588ed9547de0
https://doi.org/10.1016/j.jre.2018.06.010

Zobrazit plný text záznamu

The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons

Autor: Tosifa A. Memon, Nicole Schmitt, Jackson Carter, Kevin Chase, Noemi D. Paguigan, Yannan Yan, Shrinivasan Raghuraman, Zhenjian Lin, Eric W. Schmidt, Albebson L. Lim, Christopher A. Reilly, Bo Hjorth Bentzen, Russell W. Teichert, Manju Karthikeyan, Baldomero M. Olivera, Lee S. Leavitt, Sean Christensen

Publikováno v: Paguigan, N D, Yan, Y, Karthikeyan, M, Chase, K, Carter, J, Leavitt, L S, Lim, A L, Lin, Z, Memon, T, Christensen, S, Bentzen, B H, Schmitt, N, Reilly, C A, Teichert, R W, Raghuraman, S, Olivera, B M & Schmidt, E W 2021, ' The Tunicate Metabolite 2-(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons ', ACS chemical biology, vol. 16, no. 9, pp. 1654-1662 . https://doi.org/10.1021/acschembio.1c00328

Marine tunicates produce defensive amino-acid derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)ethan-1-amine (DIMTA), but their mechanisms of action are rarely known. Using an assay-guided approach, we found that out of the many different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9884ca44604783f84921e5567db85434
https://curis.ku.dk/ws/files/285240582/The_tunicate_metabolite_2_3_5_diiodo_4_methoxyphenyl_ethan_1_.pdf

Zobrazit plný text záznamu

Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation

Autor: Mark Alexander Skarsfeldt, Yannan Yan, Bo Hjorth Bentzen, Jonas Goldin Diness

Publikováno v: Yan, Y, Skarsfeldt, M A, Diness, J G & Bentzen, B H 2021, ' Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation ', IJC Heart and Vasculature, vol. 37, 100898 . https://doi.org/10.1016/j.ijcha.2021.100898
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss, Pp 100898-(2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eee8b60d6d7bdfc553cbcd90e6869b
https://curis.ku.dk/ws/files/286414807/Small_conductance_calcium_activated_K_channel_inhibitor_decreases_stretch.pdf

Zobrazit plný text záznamu

Akademický článek

Mesoporous nanoperforators as membranolytic agents via nano- and molecular-scale multi-patterning

Autor: Yannan Yang, Shiwei Chen, Min Zhang, Yiru Shi, Jiangqi Luo, Yiming Huang, Zhengying Gu, Wenli Hu, Ye Zhang, Xiao He, Chengzhong Yu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Plasma membrane lysis is an effective anticancer strategy, which mostly relying on soluble molecular membranolytic agents. However, nanomaterial-based membranolytic agents has been largely unexplored. Herein, we introduce a mesoporous membra

Externí odkaz: https://doaj.org/article/623de434ebcd4d02b285bc767e34117b

Zobrazit plný text záznamu

Akademický článek

O2 Plasma Alternately Treated ALD-Al2O3 as Gate Dielectric for High Performance AlGaN/GaN MIS-HEMTs

Autor: Qiang Wang, Maolin Pan, Penghao Zhang, Luyu Wang, Yannan Yang, Xinling Xie, Hai Huang, Xin Hu, Min Xu

Publikováno v: IEEE Access, Vol 12, Pp 16089-16094 (2024)

This article systematically studies the AlGaN/GaN MIS-HEMTs using the O2 plasma alternately treated Al2O3 as gate dielectric. The X-ray photoelectron spectroscopy (XPS) analyses and capacitance-voltage (C-V) measurement results show that the density

Externí odkaz: https://doaj.org/article/04e1f1e0df6d4795934cd79e7a46f822

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání