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Autor:
Provost Jean, François Prod'homme, Jean Leboul, Frédéric Herman, Marc Vuilhorgne, Frédérique Lancelin, Yann Tournoux, Cecile Combeau, François Lavelle
Publikováno v:
Molecular Pharmacology. 57:553-563
A screening program aimed at the discovery of new antimicrotubule agents yielded RPR112378 and RPR115781, two natural compounds extracted from the Indian plant Ottelia alismoides. We report their isolation, structural determination, and mechanisms of