Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Yann Thomas"'
1
Akademický článek
Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells
Autor: Yann Thomas, Luca Cirillo, Costanza Panbianco, Lisa Martino, Nicolas Tavernier, Françoise Schwager, Lucie Van Hove, Nicolas Joly, Anna Santamaria, Lionel Pintard, Monica Gotta
Publikováno v: Cell Reports, Vol 15, Iss 3, Pp 510-518 (2016)
The conserved Bora protein is a Plk1 activator, essential for checkpoint recovery after DNA damage in human cells. Here, we show that Bora interacts with Cyclin B and is phosphorylated by Cyclin B/Cdk1 at several sites. The first 225 amino acids of B
Externí odkaz: https://doaj.org/article/924201aa600c4cd9aa9a611934c30191
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2
Akademický článek
PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
Autor: Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
Publikováno v: Biology Open, Vol 7, Iss 7 (2018)
The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch recepto
Externí odkaz: https://doaj.org/article/a97deb6571094184b91de9c9b335e6e2
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3
Akademický článek
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.
Autor: Yann Thomas, Daniel C Scott, Yosua Adi Kristariyanto, Jesse Rinehart, Kristopher Clark, Philip Cohen, Thimo Kurz
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199197 (2018)
The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is highly expressed in immune tissue. Here, we provide evidence that DCNL5
Externí odkaz: https://doaj.org/article/3f989371c22b411cb33e0d7bacb27014
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4
Downregulation of mitochondrial alternative oxidase affects chloroplast function, redox status and stress response in a marine diatom
Autor: Alisdair R. Fernie, Leila Tirichine, Omer Murik, Judit Prihoda, Wagner L. Araújo, Yann Thomas, Chris Bowler, Andrew E. Allen
Publikováno v: New Phytologist
New Phytologist, Wiley, 2019, 221 (3), pp.1303-1316. ⟨10.1111/nph.15479⟩
Diatom dominance in contemporary aquatic environments indicates that they have developed unique and effective mechanisms to cope with the rapid and considerable fluctuations that characterize these environments. In view of their evolutionary history
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f97c70582ef688ce0142a7ddc46036a
https://doi.org/10.1111/nph.15479
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5
PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
Autor: Jorge Merlet, Yanwu Guo, Silvia Gutnik, Yann Thomas, Rafal Ciosk, Janosch Stoecklin, Lionel Pintard, Anca Neagu
Publikováno v: Biology Open
Biology Open, Vol 7, Iss 7 (2018)
The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch recepto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7862c4dd498b1b239708427150e2b53
http://europepmc.org/articles/PMC6078339
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6
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation
Autor: Jesse Rinehart, Kristopher Clark, Daniel C. Scott, Thimo Kurz, Philip Cohen, Yann Thomas, Yosua Adi Kristariyanto
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199197 (2018)
PLoS ONE
The activity of Cullin-RING ubiquitin E3 ligases (CRL) is regulated by NEDD8 modification. DCN-like proteins promote Cullin neddylation as scaffold-like E3s. One DCNL, DCNL5, is highly expressed in immune tissue. Here, we provide evidence that DCNL5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67ed0e10fdccadc022eaab0fd219e34
https://doaj.org/article/3f989371c22b411cb33e0d7bacb27014
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7
Re-print of 'Histone extraction protocol from the two model diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana'
Autor: Leïla Tirichine, Xin Lin, Yann Thomas, Bérangère Lombard, Damarys Loew, Chris Bowler
Publikováno v: Marine Genomics. 16:67-71
Post-translational modifications of histones affect many biological processes by influencing higher order chromatin structure that affects gene and genome regulation. It is therefore important to develop methods for extracting histones while maintain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1fa7aeca6f10cdfc826d93d43c0dc6
https://doi.org/10.1016/j.margen.2014.05.003
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8
BORA-dependent PLK1 regulation: A new weapon for cancer therapy?
Autor: Monica Gotta, Lionel Pintard, Yann Thomas, Luca Cirillo
Publikováno v: Molecular & Cellular Oncology
Molecular & Cellular Oncology, Taylor et Francis, 2016, 3 (5), pp.e1199265. ⟨10.1080/23723556.2016.1199265⟩
Molecular & Cellular Oncology, Vol. 3, No 5 (2016) P. e1199265
International audience; The mitotic kinase polo like kinase 1 (PLK1) is overexpressed in many cancers and its inhibition slows down proliferation and increases apoptosis in cancer cell lines. Understanding how PLK1 is activated is therefore crucial f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3a4252b7afa70e986ee79e5b3ebff6
https://hal.archives-ouvertes.fr/hal-01494079
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9
Mitotic entry: The interplay between Cdk1, Plk1 and Bora
Autor: Alfonso Parrilla, Luca Cirillo, Yann Thomas, Monica Gotta, Anna Santamaria, Lionel Pintard
Publikováno v: Cell Cycle
Cell Cycle, Taylor & Francis, 2016, 15 (23), pp.3177-3182. ⟨10.1080/15384101.2016.1249544⟩
Cell Cycle, Vol. 15, No 23 (2016) pp. 3177-3182
International audience; Polo-like kinase 1 (Plk1) is an important mitotic kinase that is crucial for entry into mitosis after recovery from DNA damage-induced cell cycle arrest. Plk1 activation is promoted by the conserved protein Bora (SPAT-1 in C.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ed8216da534d1e88a13be0d91ffa47
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10
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
Autor: Siobhan Curran, Roland Hjerpe, Thimo Kurz, Lawrence R. Dick, Yann Thomas, Jesse Chen, Natalia Shpiro, Aleksandra Zemla
Publikováno v: Biochemical Journal
Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets many substrates, often leading to their proteasomal degrada
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26e20e7282ed98b3fda2f6be130646a
http://europepmc.org/articles/PMC3280039
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