Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yann Merlé"'
Autor:
Michel Tod, Yann Merlé
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 28:363-388
Influence of experimental design on hyperparameter estimates precision when performing a population pharmacokinetic–pharmacodynamic (PK–PD) analysis has been shown by several studies and various approaches have been proposed for optimizing or eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0229531550916a639e70a8fe24dda252
https://doi.org/10.1023/a:1011534830530
https://doi.org/10.1023/a:1011534830530
Autor:
Yann Merlé, F Mentré
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 27:85-101
Sampling times for Bayesian estimation of the pharmacokinetic parameters of an antidepressant drug, nortriptyline, during its therapeutic drug monitoring were optimized. Our attention was focused on designs including a limited number of measurements:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b119a688d1d44cf4775515025719b1
https://doi.org/10.1023/a:1020634813296
https://doi.org/10.1023/a:1020634813296
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 27:531-554
Population approaches are appealing methods for detecting then assessing drug-drug interactions mainly because they can cope with sparse data and quantify the interindividual pharmacokinetic (PK) and pharmacodynamic (PD) variability. Unfortunately th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebdbd6f566383988b68f7b912f5e89fe
https://doi.org/10.1023/a:1023290530853
https://doi.org/10.1023/a:1023290530853
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 26:689-716
The expectation of the determinant of the inverse of the population Fisher information matrix is proposed as a criterion to evaluate and optimize designs for the estimation of population pharmacokinetic (PK) parameters. Given a PK model, a measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e1a0ac631159fbfe2124f1823532d2
https://doi.org/10.1023/a:1020703007613
https://doi.org/10.1023/a:1020703007613
Publikováno v:
British Journal of Clinical Pharmacology. 44:447-453
Aims To evaluate the distribution of population kinetic parameters for clozapine and their relationship to age and gender in patients on continuous treatment with the drug. Methods Retrospective therapeutic drug monitoring data (391 samples from 241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1ba0a14dc91c0553739840208fd416
https://doi.org/10.1046/j.1365-2125.1997.t01-1-00606.x
https://doi.org/10.1046/j.1365-2125.1997.t01-1-00606.x
Autor:
Yann Merlé, France Mentré
Publikováno v:
Mathematical Biosciences. 144:45-70
This article proposes three stochastic algorithms to optimize a Bayesian design criterion for Bayesian estimation of the parameters of nonlinear regression models; this criterion is the information expected from an experiment. The first algorithm is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ca81b628b44edbc40ea17a0f1498ff
https://doi.org/10.1016/s0025-5564(97)00017-5
https://doi.org/10.1016/s0025-5564(97)00017-5
Publikováno v:
Drug Information Journal. 29:997-1019
The population approach was developed to estimate population characteristics of the pharmacokinetics (PKs) of a drug from a sparse-sampling designed experiment in a set of individuals. This approac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fdd94a7330f74c35a4b86b4d1c44c4c
https://doi.org/10.1177/009286159502900321
https://doi.org/10.1177/009286159502900321
Publikováno v:
Journal of biopharmaceutical statistics. 14(1)
The aim of this work is to quantitatively assess the impact of structural model misspecifications on the estimates of mean and interindividual variability of clearance in the context of population approaches. This assessment is conducted from simulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e8cc91d2ebbc3ddb6b1eda2f2d8dc3
https://pubmed.ncbi.nlm.nih.gov/15027510
https://pubmed.ncbi.nlm.nih.gov/15027510
Publikováno v:
Therapeutic drug monitoring. 24(1)
Therapeutic drug monitoring in neonate has been hampered by invasiveness of blood samplings raising ethical problems. A methodologic approach has been developped in adults and in children that is still unsufficiently developped in neonates, the Bayes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa82ba141ce81b61995446d36399a39
https://pubmed.ncbi.nlm.nih.gov/11805715
https://pubmed.ncbi.nlm.nih.gov/11805715
Publikováno v:
Clinical pharmacology and therapeutics. 67(6)
Background Although the therapeutic and toxic effects of netilmicin are related to its plasma concentration, its pharmacokinetics in neonates and infants and the influence of clinical and biological variables have been only partially assessed. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2626a2824a1c3a67327a4cfe07286
https://pubmed.ncbi.nlm.nih.gov/10872642
https://pubmed.ncbi.nlm.nih.gov/10872642