Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice

Autor: Yann Malaisé, Corinne Lencina, Christel Cartier, Maïwenn Olier, Sandrine Ménard, Laurence Guzylack-Piriou

Publikováno v: Environmental Health, Vol 19, Iss 1, Pp 1-11 (2020)

Abstract Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during peri

Externí odkaz: https://doaj.org/article/4d66a7c1fef240c4884ac6e7f096f416

Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells

Autor: Yann Malaisé, Laurence Guzylack-Piriou, Lydie Sparfel, Hélène Le Mentec

Publikováno v: Toxicology in Vitro
Toxicology in Vitro, 2020, 69, pp.104993. ⟨10.1016/j.tiv.2020.104993⟩
Toxicology in Vitro, Elsevier, 2020, 69, pp.104993. ⟨10.1016/j.tiv.2020.104993⟩

International audience; The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcd699970a35b1727a9417f899b5d13
https://hal.inrae.fr/hal-02945335/document

Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development

Autor: Nancy Geoffre, Eric Houdeau, Sandrine Ménard, Laurence Guzylack-Piriou, Christel Cartier, Corinne Lencina, Frédéric Lasserre, Maïwenn Olier, Cherryl Harkat, Yann Malaisé, Eric Gaultier, Isabelle Castan, Laila Lakhal

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, ⟨10.1038/s41598-017-15196-w⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, 2017, 7, ⟨10.1038/s41598-017-15196-w⟩
Scientific Reports (7), . (2017)

Epidemiology evidenced the Bisphenol A (BPA), a chemical found in daily consumer products, as an environmental contributor to obesity and type II diabetes (T2D) in Humans. However, the BPA-mediated effects supporting these metabolic disorders are sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b7edb0a932b4f41e151074e428f71c
https://doi.org/10.1038/s41598-017-15196-w

Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms

Autor: Julien Vignard, Bernard Salles, Yann Malaisé, Elisa Boutet-Robinet, Aurore Loeuillet, Gladys Mirey, Marianne Chevalier, Elisabeth Bezine

Publikováno v: Scientific Reports (6), 1-15. (2016)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.1-15. ⟨10.1038/srep36022⟩

The Cytolethal Distending Toxin (CDT), produced by many bacteria, has been associated with various diseases including cancer. CDT induces DNA double-strand breaks (DSBs), leading to cell death or mutagenesis if misrepaired. At low doses of CDT, other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b4562be92fcd209ab796b115319f68
https://doi.org/10.1038/srep36022

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

Autor: Thergiory Irrazabal, Bhupesh K. Thakur, Mingsong Kang, Yann Malaise, Catherine Streutker, Erin O. Y. Wong, Julia Copeland, Robert Gryfe, David S. Guttman, William W. Navarre, Alberto Martin

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduc

Externí odkaz: https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e5