Right Ventricular Dysfunction in Pulmonary Hypertension: Is Resistin a Promising Target?

Autor: Sarah‐Eve Lemay, Yann Grobs, Olivier Boucherat

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)

Externí odkaz: https://doaj.org/article/c426cde5bbe14621b25415099f46ea92

Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling

Autor: Sreenath Reddy Nayakanti, Aleksandra Friedrich, Poonam Sarode, Leili Jafari, Giovanni Maroli, Mario Boehm, Alice Bourgeois, Yann Grobs, Fatemeh Khassafi, Carsten Kuenne, Stefan Guenther, Swati Dabral, Jochen Wilhelm, Astrid Weiss, Astrid Wietelmann, Baktybek Kojonazarov, Wiebke Janssen, Mario Looso, Frances de Man, Steeve Provencher, Khodr Tello, Werner Seeger, Sebastien Bonnet, Rajkumar Savai, Ralph T. Schermuly, Soni Savai Pullamsetti

Publikováno v: Circulation Research, 132(11), 1468-1485. Lippincott Williams and Wilkins
Nayakanti, S R, Friedrich, A, Sarode, P, Jafari, L, Maroli, G, Boehm, M, Bourgeois, A, Grobs, Y, Khassafi, F, Kuenne, C, Guenther, S, Dabral, S, Wilhelm, J, Weiss, A, Wietelmann, A, Kojonazarov, B, Janssen, W, Looso, M, de Man, F, Provencher, S, Tello, K, Seeger, W, Bonnet, S, Savai, R, Schermuly, R T & Pullamsetti, S S 2023, ' Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling ', Circulation Research, vol. 132, no. 11, pp. 1468-1485 . https://doi.org/10.1161/CIRCRESAHA.122.321725

Background: The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments available to prevent RV failure, except

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca445c493e7f5101cd83abafca2c3ed
https://research.vumc.nl/en/publications/0ba7346f-29dc-4c64-b99e-3989f15cebaf

Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension

Autor: Junichi Omura, Sandra Breuils-Bonnet, Eve Tremblay, Alice Bourgeois, Steeve Provencher, Yann Grobs, Tsukasa Shimauchi, Geraldine Vitry, Wen-Hui Wu, Victoria Toro, Mark Orcholski, Roxane Paulin, Sandra Martineau, Valérie Nadeau, Sébastien Bonnet, Pasquale Ferraro, Charlotte Romanet, François Potus, Olivier Boucherat

Publikováno v: Thorax. 77:247-258

BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are even worse when IPF results in secondary pulmonary hypertension (PH). Imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ae239beee2050e9a91d1c3a7d936c9a
https://doi.org/10.1136/thoraxjnl-2021-217377

Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

Autor: Tatiana V. Kudryashova, Swati Dabral, Sreenath Nayakanti, Arnab Ray, Dmitry A. Goncharov, Theodore Avolio, Yuanjun Shen, Analise Rode, Andressa Pena, Lifeng Jiang, Derek Lin, Jeffrey Baust, Timothy N. Bachman, Johannes Graumann, Clemens Ruppert, Andreas Guenther, Mario Schmoranzer, Yann Grobs, Sarah Eve Lemay, Eve Tremblay, Sandra Breuils-Bonnet, Olivier Boucherat, Ana L. Mora, Horace DeLisser, Jing Zhao, Yutong Zhao, Sébastien Bonnet, Werner Seeger, Soni S. Pullamsetti, Elena A. Goncharova

Publikováno v: Circulation research, vol 130, iss 5
Circ Res

Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial hypertension (PAH) manifests by increased proliferation and survival of pulmona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5416620a6cb4d33ae500b90e9112d7fa
https://escholarship.org/uc/item/5f69r333

Abstract 13184: ATP Citrate Lyase a New Therapeutic Target for Vascular Remodeling Diseases

Autor: Yann Grobs, Sarah-eve Lemay, Charlotte Romanet, Sandra Breuils Bonnet, Mark Orcholski, Alice Bourgeois, Melanie Sauvaget, Kana Shimauchi, Pierre Voisine, Roxane Paulin, Francois Potus, Steeve Provencher, Olivier BOUCHERAT, Sebastien Bonnet

Publikováno v: Circulation. 144

Vascular remodeling diseases (VRD) like coronary artery diseases or in-stent restenosis are characterized by proliferative and apoptosis-resistant vascular smooth muscle cells (VSMCs). As in cancer, proliferative VSMCs have increased Warburg effect l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a39af1f4c7744c683bd727270c153a3
https://doi.org/10.1161/circ.144.suppl_1.13184