Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Yann Dessi"'
Autor:
Smith Julian Duncan, David A. Entwistle, Christopher P. Ashcroft, Yann Dessi, Adrian Longstaff, Lynsey C. Hesmondhalgh
Publikováno v:
Organic Process Research & Development. 16:470-483
This article describes the selection, process development, and scale-up of a synthetic route to a complex nucleoside analogue, the A2a agonist UK-432,097 (1), that culminated in the manufacture of over 25 kg of the API. The key steps in the process w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21b0a30f99a64351406f69ace4beaf2a
https://doi.org/10.1021/op200365n
https://doi.org/10.1021/op200365n
Autor:
Smith Julian Duncan, Stephen Challenger, Alan John Pettman, Fox Darrell E, Pierre Pascal, Lynsey C. Hesmondhalgh, Yann Dessi
Publikováno v:
Organic Process Research & Development. 12:575-583
The development and utilization of a scaleable process for the manufacture of the A2a agonist UK-371,104 (1) is described. Key steps in the synthesis include (i) a palladium-catalyzed cyanation reaction to prepare the nitrile 10, (ii) a telescoped co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f75768328e2dd8d4fe7176397ea66a
https://doi.org/10.1021/op700248t
https://doi.org/10.1021/op700248t
Autor:
Stephen Challenger, Yann Dessi, Darrell E. Fox, Lynsey C. Hesmondhalgh, Pierre Pascal, Alan J. Pettman, Julian D. Smith
Publikováno v:
Organic Process Research & Development; May2008, Vol. 12 Issue 4, p575-583, 9p