Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Yann Decker"'
Autor:
Yann Decker, Jonas Krämer, Li Xin, Andreas Müller, Anja Scheller, Klaus Fassbender, Steven T. Proulx
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF
Externí odkaz:
https://doaj.org/article/52e23287c5dc4c3e87a055da4224419a
Autor:
Katrin Anne Becker, Ramona Halmer, Laura Davies, Brian D. Henry, Regan Ziobro-Henry, Yann Decker, Yang Liu, Erich Gulbins, Klaus Fassbender, Silke Walter
Publikováno v:
Neurosignals, Vol 25, Iss 1, Pp 88-97 (2017)
Background: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms
Externí odkaz:
https://doaj.org/article/af96f4fd834c48758e036fee0112c0e6
Autor:
Qinghua Luo, Laura Schnöder, Wenlin Hao, Kathrin Litzenburger, Yann Decker, Inge Tomic, Michael D. Menger, Yang Liu, Klaus Fassbender
Publikováno v:
Aging Cell. 21
Alzheimer's disease (AD), the most common cause of dementia in the elderly, is pathologically characterized by extracellular deposition of amyloid-β peptides (Aβ) and microglia-dominated inflammatory activation in the brain. p38α-MAPK is activated
Autor:
Yann, Decker, Jonas, Krämer, Li, Xin, Andreas, Müller, Anja, Scheller, Klaus, Fassbender, Steven T, Proulx
Publikováno v:
JCI insight. 7(3)
The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF
Autor:
Michael D. Menger, Wenlin Hao, Laura Schnöder, Kathrin Litzenburger, Qinghua Luo, Yann Decker, Inge Tomic, Klaus Fassbender, Yang Liu
Microglial activation is a hall marker of Alzheimer’s disease (AD); its pathogenic role and regulating mechanisms are unclear. p38α-MAPK, a stress-responding kinase, is activated in AD brain in early disease stages. In APP-transgenic mice, we dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eba4a6ce5fcc751f49f71f0c524f078
https://doi.org/10.1101/2021.10.18.464870
https://doi.org/10.1101/2021.10.18.464870
Autor:
Yann Decker, Axel Chemla, Robert Schomburg, Eszter Németh, Klaus Fassbender, Lívia Fülöp, Yang Liu, Michael D. Menger
Using publicly available data sets, we compared pH in the human brain and the cerebrospinal fluid (CSF) of postmortem control and Alzheimer's disease cases. We further investigated the effects of long-term acidosis in vivo in the APP-PS1 mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd03686165ed73d35ee1d23778612542
https://doi.org/10.1016/j.neurobiolaging.2020.12.007
https://doi.org/10.1016/j.neurobiolaging.2020.12.007
Autor:
Yang Liu, Epameinondas Lyros, Andreas Ragoschke-Schumm, Wolfgang Reith, Panagiotis Kostopoulos, Stefania Kalampokini, Alexandra Sehr, Martin Backens, Martin Lesmeister, Klaus Fassbender, Yann Decker
Publikováno v:
Neurobiology of aging
It is unclear whether alterations in cerebral pH underlie Alzheimer's disease (AD) and other dementias. We performed proton spectroscopy after oral administration of histidine in healthy young and elderly persons and in patients with mild cognitive i
Publikováno v:
Ma, Qiaoli; Decker, Yann; Müller, Andreas; Ineichen, Benjamin V; Proulx, Steven T. (2019). Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels. Journal of experimental medicine, 216(11), pp. 2492-2502. Rockefeller University Press 10.1084/jem.20190351
Journal of Experimental Medicine, 216 (11)
The Journal of Experimental Medicine
Journal of Experimental Medicine, 216 (11)
The Journal of Experimental Medicine
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lympha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c90ff613228d73e96999cbd87271f3
https://boris.unibe.ch/134685/1/2492.full.pdf
https://boris.unibe.ch/134685/1/2492.full.pdf
Autor:
Michael D. Menger, Eszter Németh, Yann Decker, Walter J. Schulz-Schaeffer, Yang Liu, Andreas Müller, Marc Fatar, Klaus Fassbender
Publikováno v:
Brain Structure and Function
The brain vasculature can be investigated in different ways ranging from in vivo to biochemical analysis. Immunohistochemistry is a simple and powerful technique that can also be applied to archival tissues. However, staining of brain vessels on para
Autor:
Steven T. Proulx, Markus Rudin, Yann Decker, Felix Schlegel, Michael Weller, Qiaoli Ma, Samia B. Bachmann, Hannah Schneider, Michael Detmar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, 9
Ma, Qiaoli; Schlegel, Felix; Bachmann, Samia B; Schneider, Hannah; Decker, Yann; Rudin, Markus; Weller, Michael; Proulx, Steven T.; Detmar, Michael (2019). Lymphatic outflow of cerebrospinal fluid is reduced in glioma. Scientific reports, 9(1), p. 14815. Springer Nature 10.1038/s41598-019-51373-9
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, 9
Ma, Qiaoli; Schlegel, Felix; Bachmann, Samia B; Schneider, Hannah; Decker, Yann; Rudin, Markus; Weller, Michael; Proulx, Steven T.; Detmar, Michael (2019). Lymphatic outflow of cerebrospinal fluid is reduced in glioma. Scientific reports, 9(1), p. 14815. Springer Nature 10.1038/s41598-019-51373-9
Glioblastoma is a malignant brain tumor with mean overall survival of less than 15 months. Blood vessel leakage and peritumoral edema lead to increased intracranial pressure and augment neurological deficits which profoundly decrease the quality of l