Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Yann Cheli"'
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Akademický článek
LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition
Autor: Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-18 (2023)
Abstract Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumor
Externí odkaz: https://doaj.org/article/1a3e75bad0684eebb8afbad93d505cd9
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3
Akademický článek
ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity
Autor: Yann Cheli, Meri K. Tulic, Najla El Hachem, Nicolas Nottet, Arnaud Jacquel, Maeva Gesson, Thomas Strub, Karine Bille, Alexandra Picard-Gauci, Henri Montaudié, Guillaume E. Beranger, Thierry Passeron, Pierre Close, Corine Bertolotto, Robert Ballotti
Publikováno v: Molecular Cancer, Vol 20, Iss 1, Pp 1-5 (2021)
Abstract Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies
Externí odkaz: https://doaj.org/article/a109a58f73fa4ac585009c1946fc3fba
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4
Akademický článek
The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?
Autor: Robert Ballotti, Yann Cheli, Corine Bertolotto
Publikováno v: Molecular Cancer, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is limited by primary and acquired resistance. The molecular determinants of the resistance have been extensively studied, but these discoveries have no
Externí odkaz: https://doaj.org/article/e356ec7b9fdf481db44e3867ff78144c
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5
Akademický článek
Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo
Autor: Meri K. Tulic, Elisa Cavazza, Yann Cheli, Arnaud Jacquel, Carmelo Luci, Nathalie Cardot-Leccia, Hanene Hadhiri-Bzioueche, Patricia Abbe, Maéva Gesson, Laura Sormani, Claire Regazzetti, Guillaume E. Beranger, Cedric Lereverend, Caroline Pons, Abdallah Khemis, Robert Ballotti, Corine Bertolotto, Stéphane Rocchi, Thierry Passeron
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased pri
Externí odkaz: https://doaj.org/article/7ccace62b4554630a57bcf27df328dfb
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