Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia

Autor: Solène Barbeau, Alexandre Joushomme, Yann Chappe, Guillaume Cardouat, Isabelle Baudrimont, Véronique Freund-Michel, Christelle Guibert, Roger Marthan, Patrick Berger, Pierre Vacher, Yann Percherancier, Jean-François Quignard, Thomas Ducret

Publikováno v: Biomolecules, Vol 12, Iss 7, p 954 (2022)

Transient receptor potential vanilloid 4 (TRPV4) is a polymodal Ca2+-permeable channel involved in various hypoxia-sensitive pathophysiological phenomena. Different tools are available to study channel activity, requiring cells to be cultured at spec

Externí odkaz: https://doaj.org/article/a5dbf282674240718c056e11d5ad242f

High-Throughput Screening of TRPV1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique

Autor: Christelle Franchet, Pauline Michel, Vincent Compan, Thomas Ducret, Solène Barbeau, Alexandre Joushomme, Florence Poulletier de Gannes, Stanislas Mayer, Sandra Pierredon, André Garenne, Yann Chappe, Annabelle Hurtier, Jean-François Quignard, Isabelle Lagroye, Y. Percherancier, Luc Baron

Publikováno v: Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2021, 100 (3), pp.237-257. ⟨10.1124/molpharm.121.000271⟩

International audience; Ion channels are attractive drug targets for many therapeutic applications. However, high-throughput screening (HTS) of drug candidates is difficult and remains very expensive. We thus assessed the suitability of the biolumine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c29b88c9bf57b40568b5053b212a2c1
https://hal.archives-ouvertes.fr/hal-03428370

Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique

Autor: Isabelle Lagroye, Denis Habauzit, Delia Arnaud-Cormos, Annabelle Hurtier, Yann Chappe, Yves Le Dréan, Catherine Martin, Hermanus J. Ruigrok, André Garenne, Emmanuelle Poque, Yann Percherancier, Philippe Lévêque, Florence Poulletier de Gannes

Publikováno v: Cell Stress and Chaperones
Cell Stress and Chaperones, 2021, 26 (1), pp.241-251. ⟨10.1007/s12192-020-01172-3⟩
Cell Stress and Chaperones, Springer Verlag, 2021, 26 (1), pp.241-251. ⟨10.1007/s12192-020-01172-3⟩
Cell Stress Chaperones

As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (≥ 1 °C) under high-level exposure. Yet, the possibility that environmental RF impact living ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3280633da1e67cc2607504178ef87c5
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02996055/document