Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.

Autor: Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane

Publikováno v: PLoS Pathogens, Vol 17, Iss 4, p e1009526 (2021)

HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression to AIDS. However, counterexamples to this para

Externí odkaz: https://doaj.org/article/f6a51f49aafc435696f3d3a1a1dc8d6f

A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B.

Autor: Lucile Warter, Lisette Cohen, Yann Benureau, Deborah Chavez, Yan Yang, Francis Bodola, Stanley M Lemon, Cinzia Traboni, Robert E Lanford, Annette Martin

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4419 (2009)

GB virus B (GBV-B) is closely related to hepatitis C virus (HCV), infects small non-human primates, and is thus a valuable surrogate for studying HCV. Despite significant differences, the 5' nontranslated RNAs (NTRs) of these viruses fold into four s

Externí odkaz: https://doaj.org/article/12b9ebe19ecc4ede96a7cb92a8bd2a90

Replication intermediate architecture reveals the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells

Autor: Pauline Dupaigne, Caroline Pouvelle, Eric Le Cam, Eliana Moreira Tavares, Patricia Kannouche, Emmanuelle Despras, Yann Benureau

DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT) pathways overcome these obstacles and allow completion of DNA synthesis by the use of specialised translesion (TLS) DNA polymerases or through recombination-related proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170c96d2e5a00f237bfa4cdf9026e5f3
https://hal.archives-ouvertes.fr/hal-03119423

Guidelines for cloning, expression, purification and functional characterization of primary HIV-1 envelope glycoproteins

Autor: Javier García-Pérez, Yann Benureau, Philippe Colin, Isabelle Staropoli, Fernando Arenzana-Seisdedos, José Alcamí, Bernard Lagane, Nuria González

Publikováno v: Journal of virological methods. 236

The trimeric HIV-1 envelope (Env) glycoproteins gp120 and gp41 mediate virus entry into target cells by engaging CD4 and the coreceptors CCR5 or CXCR4 at the cell surface and driving membrane fusion. Receptor/gp120 interactions regulate the virus lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423fc7b52543c0bbfecd80ba71549e6d
https://pubmed.ncbi.nlm.nih.gov/27451265

HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

Autor: Yongjin Wang, Fernando Arenzana-Seisdedos, Nuria González, Yann Benureau, Oliver Hartley, Philippe Colin, Anne Brelot, Bernard Lagane, Isabelle Staropoli, José Alcamí

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (23), pp.9475-9480. ⟨10.1073/pnas.1222205110⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (23), pp.9475-9480. ⟨10.1073/pnas.1222205110⟩
Proceedings of the National Academy of Sciences, Vol. 110, No 23 (2013) pp. 9475-80

CC chemokine receptor 5 (CCR5) is a receptor for chemokines and the coreceptor for R5 HIV-1 entry into CD4 + T lymphocytes. Chemokines exert anti–HIV-1 activity in vitro, both by displacing the viral envelope glycoprotein gp120 from binding to CCR5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e378a5be9ae74ef9ead105ed40ebb1a9
https://hal-pasteur.archives-ouvertes.fr/pasteur-00825629/document