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Akademický článek

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

Autor: Amandine Duchemin, Tina O’Grady, Sarah Hanache, Agnès Mereau, Marc Thiry, Ludivine Wacheul, Catherine Michaux, Eric Perpète, Eric Hervouet, Paul Peixoto, Felix G. M. Ernst, Yann Audic, Franck Dequiedt, Denis L. J. Lafontaine, Denis Mottet

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

In yeast, TFIP11 and DHX15 promote the disassembly of spliceosome complex after splicing is completed. Here the authors show that human TFIP11 functions independently of DHX15 and is required for U6 snRNA 2’-O-methylation and U4/U6.U5 tri-snRNP ass

Externí odkaz: https://doaj.org/article/93d4369760d94698a2204e30cd575392

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Akademický článek

High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology

Autor: Archana D. Siddam, Matthieu Duot, Sarah Y. Coomson, Deepti Anand, Sandeep Aryal, Bailey A. T. Weatherbee, Yann Audic, Luc Paillard, Salil A. Lachke

Publikováno v: Cells, Vol 12, Iss 7, p 1070 (2023)

Defects in the development of the ocular lens can cause congenital cataracts. To understand the various etiologies of congenital cataracts, it is important to characterize the genes linked to this developmental defect and to define their downstream p

Externí odkaz: https://doaj.org/article/0cf37258f0814ba39811a89a6d23ad07

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Akademický článek

RNA-Seq Analysis of an Antisense Sequence Optimized for Exon Skipping in Duchenne Patients Reveals No Off-Target Effect

Autor: Claire Domenger, Marine Allais, Virginie François, Adrien Léger, Emilie Lecomte, Marie Montus, Laurent Servais, Thomas Voit, Philippe Moullier, Yann Audic, Caroline Le Guiner

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 277-291 (2018)

Non-coding uridine-rich small nuclear RNAs (UsnRNAs) have emerged in recent years as effective tools for exon skipping for the treatment of Duchenne muscular dystrophy (DMD), a degenerative muscular genetic disorder. We recently showed the high capac

Externí odkaz: https://doaj.org/article/b56772ff2df9496ca4c2cf486504309a

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Akademický článek

Xenopus Resources: Transgenic, Inbred and Mutant Animals, Training Opportunities, and Web-Based Support

Autor: Marko Horb, Marcin Wlizla, Anita Abu-Daya, Sean McNamara, Dominika Gajdasik, Takeshi Igawa, Atsushi Suzuki, Hajime Ogino, Anna Noble, Centre de Ressource Biologique Xenope team in France, Jacques Robert, Christina James-Zorn, Matthew Guille, Morgane Nicolas, Thomas Lafond, Daniel Boujard, Yann Audic, Brigitte Guillet

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Two species of the clawed frog family, Xenopus laevis and X. tropicalis, are widely used as tools to investigate both normal and disease-state biochemistry, genetics, cell biology, and developmental biology. To support both frog specialist and non-sp

Externí odkaz: https://doaj.org/article/517a3ba5a3ee446b88be700ee1c23185

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Akademický článek

Identification of CELF1 RNA targets by CLIP-seq in human HeLa cells

Autor: Olivier Le Tonquèze, Bernhard Gschloessl, Vincent Legagneux, Luc Paillard, Yann Audic

Publikováno v: Genomics Data, Vol 8, Iss C, Pp 97-103 (2016)

The specific interactions between RNA-binding proteins and their target RNAs are an essential level to control gene expression. By combining ultra-violet cross-linking and immunoprecipitation (CLIP) and massive SoliD sequencing we identified the RNAs

Externí odkaz: https://doaj.org/article/5f8af2b8f6664b4ba973736545a2531d

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Akademický článek

Design and Use of Easily Made RNA Size Markers

Autor: Yann Audic, Francis Omilli, H. Beverley Osborne, Laëtitia Landais

Publikováno v: BioTechniques, Vol 23, Iss 4, Pp 612-616 (1997)

Externí odkaz: https://doaj.org/article/447d0f79e5c649bebf0560d182838353

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Akademický článek

Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice.

Autor: Marie Cibois, Gaella Boulanger, Yann Audic, Luc Paillard, Carole Gautier-Courteille

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46337 (2012)

BACKGROUND: The first wave of spermatogenesis in mammals is characterized by a sequential and synchronous appearance of germ cells in the prepubertal testis. Post-transcriptional controls of gene expression play important roles in this process but th

Externí odkaz: https://doaj.org/article/b78705798992462da7f37dbd90215082

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The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the alternative splicing of CD44

Autor: Géraldine David, David Reboutier, Stéphane Deschamps, Agnès Méreau, William Taylor, Sergi Padilla-Parra, Marc Tramier, Yann Audic, Luc Paillard

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 2022, 626, pp.79-84. ⟨10.1016/j.bbrc.2022.07.073⟩

International audience; CD44 mRNA contains nine consecutive cassette exons, v2 to v10. Upon alternative splicing, several isoforms are produced with different impacts on tumor biology. Here, we demonstrate the involvement of the RNA-binding proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119b7cb0f853caf50a4e9c31f2600820
https://doi.org/10.1016/j.bbrc.2022.07.073

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