Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Autor: Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J. Jasmin, Laurent Schaeffer

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Externí odkaz: https://doaj.org/article/cdf9d7e3e2ad4da9b5e4aa9491b771ee

Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

Autor: Qing Zhang, Agnès Duplany, Vincent Moncollin, Sandrine Mouradian, Evelyne Goillot, Laetitia Mazelin, Karine Gauthier, Nathalie Streichenberger, Céline Angleraux, Jie Chen, Shuzhe Ding, Laurent Schaeffer, Yann‐Gaël Gangloff

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 35-53 (2019)

Abstract Background The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial ef

Externí odkaz: https://doaj.org/article/481283996c1a43f4bda9799c846af817

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle

Autor: Zhe Song, Daniel R. Moore, Nathan Hodson, Carl Ward, Jessica R. Dent, Mary F. O’Leary, Andrew M. Shaw, D. Lee Hamilton, Sovan Sarkar, Yann-Gaël Gangloff, Troy A. Hornberger, Lawrence L. Spriet, George J. Heigenhauser, Andrew Philp

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal mus

Externí odkaz: https://doaj.org/article/71453322f31c4042b79fba8f35f34ad7

H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles

Autor: Kiran Padmanabhan, Ali Hamiche, Stefan Dimitrov, Lorrie Ramos, Christophe Papin, Defne Dalkara, Yann-Gaël Gangloff, Nicolas Lacoste, Isabella Scionti, Laurent Schaeffer, Edwige Belotti, Thomas Simonet

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48, pp.4601-4613. ⟨10.1093/nar/gkaa157⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (9), pp.4601-4613. ⟨10.1093/nar/gkaa157⟩
Nucleic Acids Research, 2020, 48 (9), pp.4601-4613. ⟨10.1093/nar/gkaa157⟩

While the histone variant H2A.Z is known to be required for mitosis, it is also enriched in nucleosomes surrounding the transcription start site of active promoters, implicating H2A.Z in transcription. However, evidence obtained so far mainly rely on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30b351fbc8d2bed8599301df8df7928
https://avesis.deu.edu.tr/publication/details/0ffef56b-2c9f-4f12-82bb-0b9bd2ad8259/oai

mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis

Autor: Geoffrey Teixeira, Emilie Delaune, Qing Zhang, Théophile Ohlmann, Daniel Taillandier, Laetitia Mazelin, Michel Ovize, Anne-Sophie Nicot, Baptiste Panthu, Yann-Gaël Gangloff, Geneviève Derumeaux, Lionel A. Tintignac, Laurent Schaeffer, Edwige Belotti, Dominique Baas, Valérie Risson

Publikováno v: Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2016, 97, pp.213-225. ⟨10.1016/j.yjmcc.2016.04.011⟩
Journal of Molecular and Cellular Cardiology, 2016, 97, pp.213-225. ⟨10.1016/j.yjmcc.2016.04.011⟩

Mechanistic target of rapamycin (mTOR) is a central regulator of cell growth, proliferation, survival and metabolism, as part of mTOR complex 1 (mTORC1) and mTORC2. While partial inhibition of mTORC1 using rapamycin was shown to be cardioprotective,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88b644a111b9891ef38f69bb11d2d83
https://hal.archives-ouvertes.fr/hal-01837643