Immunoprotective effect of von Willebrand factor towards therapeutic factor VIII in experimental haemophilia A

Autor: Sandrine Delignat, Yann Meslier, Olivier D. Christophe, Yohann Repessé, Ana-Maria Navarrete, Sébastien Lacroix-Desmazes, Nimesh Gupta, Srini V. Kaveri

Publikováno v: Haemophilia. 18:248-254

The development of inhibitory anti-factor VIII (FVIII) antibodies in patients with haemophilia A following replacement therapy is associated with several types of risk factors. Among these, the purity of FVIII concentrates, and in particular the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a1ac15f84a5b89fa5e748f0ece65887
https://doi.org/10.1111/j.1365-2516.2011.02679.x

Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance

Autor: Sune Justesen, Maxime Lecerf, Sébastien Lacroix-Desmazes, Roberto Mallone, Jordan D. Dimitrov, David W. Scott, Yann Meslier, Valérie Gouilleux-Gruart, Srinivas V. Kaveri, Slobodan Culina, Bagirath Gangadharan, Christophe Arnoult, Nimesh Gupta, Benoît L. Salomon, Sandrine Delignat

Publikováno v: Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2015, 7 (275), pp.275ra21-275ra21. ⟨10.1126/scitranslmed.aaa1957⟩
Science Translational Medicine, 2015, 7 (275), pp.275ra21-275ra21. ⟨10.1126/scitranslmed.aaa1957⟩

International audience; Central tolerance plays a key role in modulating immune responses to self and exogenous antigens. The absence of self-antigen expression, as in patients with genetic deficiencies, prevents the development of antigen-specific i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75954b3478b0a22dcba32e07781c3237
https://doi.org/10.1126/scitranslmed.aaa1957

Maternally transferred anti-factor VIII IgG reduce the anti-factor VIII humoral immune response in factor VIII-deficient mice

Autor: Yann, Meslier, Sébastien, André, Maud, Teyssandier, Srinivas V, Kaveri, Sébastien, Lacroix-Desmazes

Publikováno v: Immunology. 131(4)

Replacement therapy with exogenous factor VIII (FVIII) to treat haemorrhages or used in prophylaxis induces inhibitory anti-FVIII immunoglobulin G (IgG) in some patients with haemophilia A. Therapeutic strategies to prevent the onset of the deleterio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::022fdefe1af06609cd6c96154e1c594a
https://pubmed.ncbi.nlm.nih.gov/20673239

A cellular viewpoint of anti-FVIII immune response in hemophilia A

Autor: Yann Meslier, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov, Yohann Repessé, Sébastien André, Suryasarathi Dasgupta, Srinivas V. Kaveri

Publikováno v: Clinical reviews in allergyimmunology. 37(2)

A large proportion of hemophilia A patients who receive replacement therapy, develop an immune response toward the infused factor VIII (FVIII). In this review, we discuss recent progress in several aspects of the anti-FVIII immune response, focusing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ebed2d46b26ae21a53cb02cf1cdaac
https://pubmed.ncbi.nlm.nih.gov/19165635