Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Yann, Dudit"'
Autor:
Yann Dudit, Zehong Wan, Don O. Somers, Yingxia Sang, Vipulkumar Kantibhai Patel, Pascal Grondin, Joseph E. Coyle, Veronique Beneton, Rachel McMenamin, Lee William Page, Philip J. Day, Alison Jo-Anne Woolford, Lionel Trottet, Valerio Berdini, Florent Potvain, Sharna J. Rich, Christopher William Murray, Pascal Huet, Lydia Y. W. Lee, Xiaomin Zhang, Eric S. Manas
Publikováno v:
Journal of Medicinal Chemistry. 59:10738-10749
Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-
Autor:
Alison J-A, Woolford, Philip J, Day, Véronique, Bénéton, Valerio, Berdini, Joseph E, Coyle, Yann, Dudit, Pascal, Grondin, Pascal, Huet, Lydia Y W, Lee, Eric S, Manas, Rachel L, McMenamin, Christopher W, Murray, Lee W, Page, Vipulkumar K, Patel, Florent, Potvain, Sharna J, Rich, Yingxia, Sang, Don O, Somers, Lionel, Trottet, Zehong, Wan, Xiaomin, Zhang
Publikováno v:
Journal of medicinal chemistry. 59(23)
Lp-PLA
Autor:
Delphine Delannée, Pascal Huet, Chun-wa Chung, Anne Marie Jeanne Bouillot, Françoise Gellibert, Antonia J. Lewis, Yann Lamotte, Yann Dudit, Lionel Trottet, Jason Witherington, Olivier Mirguet, Edwige Nicodeme, Paul Bamborough, Gael Krysa
Publikováno v:
ChemMedChem. 9(3)
Bromodomains (BRDs) are small protein domains found in a variety of proteins that recognize and bind to acetylated histone tails. This binding affects chromatin structure and facilitates the localisation of transcriptional complexes to specific genes
Autor:
Jean-Marie Brusq, Pascal Grondin, Benjamin Beaufils, Frédéric Donche, Stéphane Sautet, Celine Marques, Edwige Nicodeme, Yann Dudit, Catherine-Anne Clément, Pascal Huet, Yannick Saintillan, Eric Boursier, Jérôme Toum, Mathieu Pizzonero, Emilie Rondet, Lionel Trottet, Olivier Mirguet
AMP-activated protein kinase (AMPK) is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation, enhances insulin sensitivity, alleviates hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8260bf96114fc481fec9048186ad6416
https://europepmc.org/articles/PMC4027520/
https://europepmc.org/articles/PMC4027520/
Autor:
Delphine Delannée, Agnès Costaz, Jonathan Thomas Seal, Lionel Trottet, Rémi Tellier, Jean-Marie Brusq, Olivier Mirguet, Anne Marie Jeanne Bouillot, Sandrine Martin, Gael Krysa, Anne-Benedicte Boullay, Jorge Kirilovsky, Eric Boursier, Jérôme Toum, Yann Dudit, Van-Loc Nguyen, Edwige Nicodeme, Françoise Gellibert, Alizon M. Riou, Pascal Huet, Romain Luc Marie Gosmini, Yann Lamotte, Florence Blandel, Frédéric Donche
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(8)
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.