ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing.

Autor: Justin R Pritchard, Michael C Chao, Sören Abel, Brigid M Davis, Catherine Baranowski, Yanjia J Zhang, Eric J Rubin, Matthew K Waldor

Publikováno v: PLoS Genetics, Vol 10, Iss 11, p e1004782 (2014)

Transposon-insertion sequencing (TIS) is a powerful approach for deciphering genetic requirements for bacterial growth in different conditions, as it enables simultaneous genome-wide analysis of the fitness of thousands of mutants. However, current m

Externí odkaz: https://doaj.org/article/6d11aade0796443b8c585fe1b3afa10e

Global assessment of genomic regions required for growth in Mycobacterium tuberculosis.

Autor: Yanjia J Zhang, Thomas R Ioerger, Curtis Huttenhower, Jarukit E Long, Christopher M Sassetti, James C Sacchettini, Eric J Rubin

Publikováno v: PLoS Pathogens, Vol 8, Iss 9, p e1002946 (2012)

Identifying genomic elements required for viability is central to our understanding of the basic physiology of bacterial pathogens. Recently, the combination of high-density mutagenesis and deep sequencing has allowed for the identification of requir

Externí odkaz: https://doaj.org/article/6682f3185353438f90677a3b6043fb3f

Correction: Global Assessment of Genomic Regions Required for Growth in.

Autor: Yanjia J. Zhang, Thomas R. Ioerger, Curtis Huttenhower, Jarukit E. Long, Christopher M. Sassetti, James C. Sacchettini, Eric J. Rubin

Publikováno v: PLoS Pathogens, Vol 9, Iss 7 (2013)

Externí odkaz: https://doaj.org/article/9f3a4a80a8324355a96800665b00443e

Feast or famine: the host-pathogen battle over amino acids

Autor: Eric J. Rubin, Yanjia J. Zhang

Publikováno v: Cellular Microbiology. 15:1079-1087

Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity. Here we discuss both host mechanisms of amino acid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b04b585c087e0b1f413563badab17f5
https://doi.org/10.1111/cmi.12140

Plasma membrane profiling reveals upregulation of ABCA1 by infected macrophages leading to restriction of mycobacterial growth

Autor: Yuxian Du, Yanjia J. Zhang, Babak Javid, Michael P. Weekes, Robin Antrobus, Duncan L. Smith, Jing Long, Robindra Basu Roy

Publikováno v: Long, J, Roy, R B, Zhang, Y J, Antrobus, R, Du, Y, Smith, D L, Weekes, M P & Javid, B 2016, ' Plasma membrane profiling reveals upregulation of ABCA1 by infected macrophages leading to restriction of mycobacterial growth ', Frontiers in Microbiology, vol. 7, no. JUL, 1086 . https://doi.org/10.3389/fmicb.2016.01086
Frontiers in Microbiology
Frontiers in Microbiology, Vol 7 (2016)

The plasma membrane represents a critical interface between the internal and extracellular environments, and harbors multiple proteins key receptors and transporters that play important roles in restriction of intracellular infection. We applied plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2b5c7e838cd05bc093315aee43d57
https://www.research.manchester.ac.uk/portal/en/publications/plasma-membrane-profiling-reveals-upregulation-of-abca1-by-infected-macrophages-leading-to-restriction-of-mycobacterial-growth(1b6eb369-ab1a-4f21-82a8-411ce47ac2ed).html