Výsledky vyhledávání - "Yanis Tolstov"

Akademický článek

Genomic features of renal cell carcinoma with venous tumor thrombus

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of

Externí odkaz: https://doaj.org/article/fdc0109087c648f893b957962fedc3ad

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Akademický článek

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour doe

Externí odkaz: https://doaj.org/article/6b8b3ea588cd4746baa64e76cce15f72

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Akademický článek

Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications

Autor: Xiaoguang Zhou, Jielin Li, Christina Marx, Yanis Tolstov, Geraldine Rauch, Esther Herpel, Stephan Macher-Goeppinger, Wilfried Roth, Carsten Grüllich, Sascha Pahernik, Markus Hohenfellner, Stefan Duensing

Publikováno v: Translational Oncology, Vol 8, Iss 6, Pp 480-486 (2015)

Renal cell carcinoma (RCC) is characterized by a profound disruption of proapoptotic signaling networks leading to chemo- and radioresistance. A key mediator of DNA damage-induced apoptosis is the BH3-only protein PUMA. Given its central role in proa

Externí odkaz: https://doaj.org/article/8ca6f6c2dc57465ebe773b08a1d1f9a5

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Akademický článek

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer

Autor: Josef Mang, Nina Korzeniewski, Dimo Dietrich, Verena Sailer, Yanis Tolstov, Sam Searcy, Jost von Hardenberg, Sven Perner, Glen Kristiansen, Alexander Marx, Wilfried Roth, Esther Herpel, Carsten Grüllich, Valentin Popeneciu, Sascha Pahernik, Boris Hadaschik, Markus Hohenfellner, Stefan Duensing

Publikováno v: Translational Oncology, Vol 8, Iss 6, Pp 487-496 (2015)

We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule n

Externí odkaz: https://doaj.org/article/b04777fa3d1e4db79f8ebebf4641d25c

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Akademický článek

Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma

Autor: Xiaoguang Zhou, Yanis Tolstov, Aysenur Arslan, Wilfried Roth, Carsten Grüllich, Sascha Pahernik, Markus Hohenfellner, Stefan Duensing

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 1028-1035 (2014)

Resistance to DNA damage–induced apoptosis is a hallmark of cancer and a major cause of treatment failure and lethal disease outcome. A tumor entity that is largely resistant to DNA-damaging therapies including chemo- or radiotherapy is renal cell

Externí odkaz: https://doaj.org/article/20e077f4dadc4848b52147716c704cc2

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