The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection

Autor: Kirsti Hornigold, Stephen Chetwynd, Elizabeth Hampson, Polly A. Machin, Dingxin Pan, Laraine Crossland, Simon J. Cleary, Simon C. Pitchford, Heidi C.E. Welch, Klaus Okkenhaug, Yanira Riffo-Vasquez, Chiara Pantarelli, Cornelis van 't Veer, Martin J. Baker, Rachael C. Walker, Anne-Katrien Stark, Anna Mandel, Anne Segonds-Pichon

Publikováno v: Blood advances, 5(16), 3076-3091. American Society of Hematology
Blood Adv

Streptococcal pneumonia is a worldwide health problem that kills ∼2 million people each year, particularly young children, the elderly, and immunosuppressed individuals. Alveolar macrophages and neutrophils provide the early innate immune response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2901761bcf9636af1b3e742ed7ee553f
https://pure.amc.nl/en/publications/the-gpcr-adaptor-protein-norbin-suppresses-the-neutrophilmediated-immunity-of-mice-to-pneumococcal-infection(852e42a4-5589-4e0b-9444-05df17c30353).html

Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3

Autor: Christopher Corrigan, Alan L. James, Sajeel A. Shah, Yanira Riffo-Vasquez, John G. Elliot, Clive P. Page, Zainab Mohamed, Simon C. Pitchford, Varsha Kanabar, Janis K. Shute, Simon J. Cleary

Publikováno v: Shah, S A, Kanabar, V, Riffo-Vasquez, Y, Mohamed, Z, Cleary, S J, Corrigan, C, James, A L, Elliott, J G, Shute, J K, Page, C P & Pitchford, S C 2021, ' Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3 ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 5, pp. 557–568 . https://doi.org/10.1165/rcmb.2020-0425OC
American Journal of Respiratory Cell and Molecular Biology

Platelet activation and pulmonary recruitment occur in patients with asthma and in animal models of allergic asthma, in which leukocyte infiltration, airway remodeling, and hyperresponsiveness are suppressed by experimental platelet depletion. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec64117fa68f54360c906d25df93a078
https://kclpure.kcl.ac.uk/ws/files/155174783/rcmb.2020_0425oc.pdf

Sex differences in the influence of obesity on a murine model of allergic lung inflammation

Autor: Gabriel Forato Anhê, Yanira Riffo-Vasquez, Rodrigo Rodrigues e‐Lacerda, Clive P. Page

Publikováno v: Riffo Vasquez, Y D L A, Rodrigues e-Lacerda, R, Forato Anhe, G & Page, C P 2020, ' Sex differences in the influence of obesity on a murine model of allergic lung inflammation ', Clinical and Experimental Allergy, vol. 50, no. 2, pp. 256-266 . https://doi.org/10.1111/cea.13541

Background: Despite the overwhelming evidence showing the influence of sex or obesity in the development of respiratory diseases in humans and animals, the mechanisms by which these combined two factors influence allergic asthma are not well understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd25312f15e58be952b5fb0464e8092
https://kclpure.kcl.ac.uk/en/publications/0603c003-ccb2-4f3e-b7e8-cb0dd7efa587

Steroid sparing effects of doxofylline

Autor: Clive P. Page, Radhakrishnan Venkatasamy, Yanira Riffo-Vasquez

Publikováno v: Riffo-Vasquez, Y, Venkatasamy, R & Page, C P 2018, ' Steroid sparing effects of doxofylline ', Pulmonary pharmacology & therapeutics . https://doi.org/10.1016/j.pupt.2017.10.008

Glucocorticosteroids are widely used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). However, there are growing concerns about the side effect profile of this class of drug, particularly an increased risk of pneumonia. Ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89770e9883e05e9e111c527af2846317
https://doi.org/10.1016/j.pupt.2017.10.008

Modulation of allergic inflammation in the lung by a peptide derived from Mycobacteria tuberculosis chaperonin 60.1

Autor: Sandra Keir, David A. Jackson, Clive P. Page, Francis Man, Anthony R.M. Coates, Varsha Kanabar, Yanira Riffo-Vasquez, Rodrigo Rodrigues e‐Lacerda, Valerie Corrigall

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyREFERENCES. 50(4)

Background\ud We have previously demonstrated that Mycobacteria tuberculosis chaperonin 60.1 inhibits leucocyte diapedesis and bronchial hyperresponsiveness in a murine model of allergic lung inflammation.\ud \ud Methods\ud In the present study, we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4edb07490edfe3366201900dd61187
https://pubmed.ncbi.nlm.nih.gov/31845415