PD-1 Expression in HIV-Specific CD8+ T cells Before Antiretroviral Therapy Is Associated With HIV Persistence

Autor: Horacio Salomón, María Laura Polo, Omar Sued, César Ariel Trifone, María Julia Ruiz, Sharon R Lewin, Yanina Alexandra Ghiglione, Natalia Laufer, Ajantha Rhodes, Gabriela Turk, Jimena Salido

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 80:1-6

BACKGROUND: The persistence of latently infected T cells remains the principal barrier to HIV cure. Understanding how the early immune responses shape persistence of HIV on antiretroviral therapy (ART) will be fundamental for potential eradication. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c27bda80c24d6209b755acc10a7c87
https://doi.org/10.1097/qai.0000000000001887

Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy

Autor: Horacio Salomón, Yanina Alexandra Ghiglione, Patricia Patterson, Alejandro Czernikier, Alicia Sisto, María Florencia Quiroga, Natalia Laufer, Gabriela Turk, Alejandra Urioste, Ajantha Rhodes, María José Rolón, María Laura Polo, Sharon R Lewin, César Ariel Trifone, Sonia Bakkour

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Open Forum Infectious Diseases

Background Hepatitis C virus (HCV) coinfection among people with human immunodeficiency virus (HIV) might perturb immune function and HIV persistence. We aimed to evaluate the impact of HCV clearance with direct-acting antivirals (DAAs) on immune act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b46c062fa5b2d3c9d2f651666d1db8
https://academic.oup.com/ofid/article/7/5/ofaa115/5815337

Bioinformatic analysis of post-transmission viral readaptation in Argentine patients with acute HIV-1 infection

Autor: G. Damilano, M.J. Ruiz, Horacio Salomón, F. Quiroga, Dario A. Dilernia, F. Guzman, P. Cahn, O. Sued, S. Satorres, Gabriela Turk, Yanina Alexandra Ghiglione

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

During the acute phase of HIV-1 infection, a strong readaptation occurs in the viral population. Our objective was to analyze the post-transmission mutations associated with escape to the cytotoxic immune response and its relationship with the progre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eaa9a89f882410c14e1ad660d83c344
https://pubmed.ncbi.nlm.nih.gov/31991176

Interaction between macrophage migration inhibitory factor and CD74 in human immunodeficiency virus type I infected primary monocyte-derived macrophages triggers the production of proinflammatory mediators and enhances infection of unactivated CD4+ T cells

Autor: Jimena Salido, Yanina Alexandra Ghiglione, César Ariel Trifone, Richard Bucala, María Florencia Quiroga, Gabriela Turk, María Julia Ruiz, Lin Leng, Horacio Salomón

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Understanding the mechanisms of human immunodeficiency virus type I (HIV-1) pathogenesis would facilitate the identification of new therapeutic targets to control the infection in face of current antiretroviral therapy limitations. CD74 membrane expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971382a3a836a914e483c9556b74cb47
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01494/full

Biomarkers of progression after HIV acute/early infection: Nothing compares to CD4+ T-cell count?

Autor: María Magdalena Gherardi, Jimena Salido, María Paula Caruso, María A. Pando, Omar Sued, María Julia Ruiz, Luis D. Giavedoni, Roberto Daniel Rabinovich, María Pía Holgado, Horacio Salomón, Juliana Falivene, Yanina Alexandra Ghiglione, César Ariel Trifone, Macarena Hormanstorfer, Natalia Laufer, Gabriela Turk, Romina Soledad Coloccini, María Inés Figueroa, Pedro A. Pury

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Viruses; Volume 10; Issue 1; Pages: 34
Viruses, Vol 10, Iss 1, p 34 (2018)
Viruses

Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6843233d88e6ec0495cdc6c9899fc93e
http://www.mdpi.com/1999-4915/10/1/34