Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yanick Bertrand"'
Autor:
Yanick Bertrand, Michel Demeule, Hervé Sartelet, Julie Poirier, Dorothy Fatehi, Danica Stanimirovic, Jean-Christophe Currie, Richard Béliveau, Jean-Paul Castaigne, Abedelnasser Abulrob
Publikováno v:
British Journal of Cancer
Background: ANG1005 consists of three molecules of paclitaxel conjugated via ester bonds to the 19-amino-acid peptide Angiopep-2. The new chemical agent has been shown to cross the blood–brain barrier (BBB) by receptor-mediated transcytosis via low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53b37934e2e38bcf7a810886688cf72
https://doi.org/10.1038/bjc.2011.427
https://doi.org/10.1038/bjc.2011.427
Autor:
Anthony Regina, Reinhard Gabathuler, Richard Béliveau, Dorothy Fatehi, Abedelnasser Abulrob, Yanick Bertrand, Christian Che, Jean-Christophe Currie, Jean-Paul Castaigne, Hervé Sartelet, Michel Demeule, Danica Stanimirovic
Publikováno v:
Journal of Cellular and Molecular Medicine
New and effective therapeutics that cross the blood-brain barrier (BBB) are critically needed for treatment of many brain diseases. We characterize here a novel drug development platform that is broadly applicable for the development of new therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa8325f727e1619fa72f4fb244ad633
https://doi.org/10.1111/j.1582-4934.2009.00930.x
https://doi.org/10.1111/j.1582-4934.2009.00930.x
Autor:
Jean-Christophe Currie, Yanick Bertrand, Jean-Paul Castaigne, Reinhard Gabathuler, Richard Béliveau, Tran Nguyen, Michel Demeule, Christian Che, Anthony Regina
Publikováno v:
Journal of Neurochemistry. 106:1534-1544
The blood-brain barrier (BBB) restricts the entry of proteins as well as potential drugs to cerebral tissues. We previously reported that a family of Kunitz domain-derived peptides called Angiopeps can be used as a drug delivery system for the brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1f76e3868f5fbbfe2a9f11fa0db344
https://doi.org/10.1111/j.1471-4159.2008.05492.x
https://doi.org/10.1111/j.1471-4159.2008.05492.x
Autor:
Michel Demeule, Quynh-Tran Nguyen, Serge Gauthier, Yanick Bertrand, Malcolm L. Kennard, Richard Béliveau, Richard R. Desrosiers, Reinhard Gabathuler
Publikováno v:
Biochemical Journal. 374:463-471
Levels of soluble melanotransferrin in serum have been reported to be higher in patients with Alzheimer's disease than in control subjects. The present study investigated melanotransferrin in human body fluids in the light of these findings. To clari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c0d692115b35923be3a4e258e1228f
https://doi.org/10.1042/bj20030240
https://doi.org/10.1042/bj20030240
Autor:
Richard R. Desrosiers, Delara Karkan, Tran Nguyen, Julie Lanthier, Yanick Bertrand, Wilfred A. Jefferies, Michel Demeule, Sam Tsai, Roméo Cecchelli, Claude Dagenais, Richard Béliveau, Julie Poirier, Laurence Fenart, Reinhard Gabathuler, Malcolm L. Kennard, Julie Jodoin
Publikováno v:
Journal of Neurochemistry. 83:924-933
The blood-brain barrier (BBB) performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins as well as pharmacological agents to cerebral tissues. We demonstrate here that recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32b811d53514191597be9e934b79bb17
https://doi.org/10.1046/j.1471-4159.2002.01201.x
https://doi.org/10.1046/j.1471-4159.2002.01201.x
Autor:
Denis Gingras, Jonathan Michaud-Levesque, Julie Jodoin, Sylvie Lamy, Richard Béliveau, Dominique Boivin, Borhane Annabi, Yanick Bertrand, Michel Demeule
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 2:441-463
The concept of cancer prevention by use of naturally occuring substances that could be included in the diet is under investigation as a practical approach towards reducing cancer incidence, and therefore the mortality and morbidity associated with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33cccb9acbefcb9397822dd9fe3fd90
https://doi.org/10.2174/1568011023353930
https://doi.org/10.2174/1568011023353930
Autor:
Yanick Bertrand, Jean-Paul Castaigne, Danica Stanimirovic, Richard Béliveau, Anthony Regina, Jean-Christophe Currie, Michel Demeule
The most common primary brain tumour is glioblastoma multiforme (GBM). Despite latest cancer researches to improve the outcome of patients with GBM, this highly aggressive tumour remains one of the most difficult tumors to treat. Angiochem's Engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0661799b06af793d90db2bb368817f7a
https://nrc-publications.canada.ca/eng/view/object/?id=3eb1892f-5064-4689-9189-e24df9ad9ddb
https://nrc-publications.canada.ca/eng/view/object/?id=3eb1892f-5064-4689-9189-e24df9ad9ddb
Publikováno v:
Biochemical and biophysical research communications. 353(2)
The expression of melanotransferrin (MTf), a membrane-bound glycoprotein highly expressed in melanomas, is correlated with tumor vascularization and progression, suggesting a proinvasive function associated with MTf in malignant tumors. To test this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef711a957cf7c90591179f359149951
https://pubmed.ncbi.nlm.nih.gov/17196552
https://pubmed.ncbi.nlm.nih.gov/17196552
Autor:
Michel Demeule, Anthony Regina, Michel W. Bojanowski, Yanick Bertrand, Richard Béliveau, Borhane Annabi
Publikováno v:
Molecular neurobiology. 30(2)
The blood-brain barrier contributes to brain homeostasis by controlling the access of nutrients and toxic substances to the central nervous system (CNS). The acquired brain endothelial cells phenotype results from their sustained interactions with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab4fa7af38e8ed63b82f1a6d7b58bc8
https://pubmed.ncbi.nlm.nih.gov/15475625
https://pubmed.ncbi.nlm.nih.gov/15475625
Autor:
Yannève Rolland, Reinhard Gabathuler, Michel Demeule, Jonathan Michaud-Levesque, Richard Béliveau, Yanick Bertrand, Julie Jodoin
Publikováno v:
Blood. 102(5)
We recently reported that human recombinant melanotransferrin (p97) presents a high transport rate across the blood-brain barrier that might involve the low-density lipoprotein receptor–related protein (LRP). We now report new interactions between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07d32a98a9384940ce58e69585b64e
https://pubmed.ncbi.nlm.nih.gov/12750156
https://pubmed.ncbi.nlm.nih.gov/12750156