Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Yanhui Liang"'
Autor:
Weikai Ge, Shixue Gou, Xiaozhu Zhao, Qin Jin, Zhenpeng Zhuang, Yu Zhao, Yanhui Liang, Zhen Ouyang, Xiaoyi Liu, Fangbing Chen, Hui Shi, Haizhao Yan, Han Wu, Liangxue Lai, Kepin Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene therapy. However, there are concerns about the safety of this system, specifically related to the use of guide-free Cas9. Previous studies have
Externí odkaz:
https://doaj.org/article/d5821f95cdce4ed0a2e9fbac9fb1c3f0
Autor:
Weikai Ge, Xiaozhu Zhao, Shixue Gou, Qin Jin, Fangbing Chen, Zhen Ouyang, Chengdan Lai, Tao Cui, Baoyi Mai, Sijia Lu, Kexin Zhong, Yanhui Liang, Tao Chen, Han Wu, Nan Li, Yinghua Ye, Liangxue Lai, Kepin Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102035- (2023)
Cas9 protein without sgRNAs can induce genomic damage at the cellular level in vitro. However, whether the detrimental effects occur in embryos after Cas9 treatment remains unknown. Here, using pig embryos as subjects, we observed that Cas9 protein t
Externí odkaz:
https://doaj.org/article/bbe5b6b43aba40698fb60acc055ce682
Autor:
Lei Xu, Shichao Kan, Xiying Yu, Ye Liu, Yuxia Fu, Yiqiang Peng, Yanhui Liang, Yigang Cen, Changjun Zhu, Wei Jiang
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108145- (2023)
Summary: Despite its remarkable potential for transforming low-resolution images, deep learning faces significant challenges in achieving high-quality superresolution microscopy imaging from wide-field (conventional) microscopy. Here, we present X-Mi
Externí odkaz:
https://doaj.org/article/1eb7bb5ea2ca46b499c5689a6588e744
Autor:
Fangbing Chen, Meng Lian, Bingxiu Ma, Shixue Gou, Xian Luo, Kaiming Yang, Hui Shi, Jingke Xie, Weika Ge, Zhen Ouyang, Chengdan Lai, Nan Li, Quanjun Zhang, Qin Jin, Yanhui Liang, Tao Chen, Jiaowei Wang, Xiaozhu Zhao, Lei Li, Manya Yu, Yinghua Ye, Kepin Wang, Han Wu, Liangxue Lai
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Cas12a-mediated cytosine (CBE) and adenine base editor (ABE) systems with elevated efficiencies and expanded target scopes are developed, by combining highly active deaminases with Cas12a variants, enCas12a, RR and RVR, recognizing non-TTTV PAMs.
Externí odkaz:
https://doaj.org/article/a070b51af0f64766bd9a718411c97efb
Autor:
Yingyin Liao, Liang Xue, Junshan Gao, Yueting Zuo, Yanhui Liang, Yueting Jiang, Weicheng Cai, Jiale Yang, Jumei Zhang, Yu Ding, Moutong Chen, Aiwu Wu, Xiaoxia Kou, Qingping Wu
Publikováno v:
Gut Pathogens, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract The emergence of the novel GII.17 Kawasaki 2014 norovirus variant raising the interest of the public, has replaced GII.4 as the predominant cause of noroviruses outbreaks in East Asia during 2014–2015. Antigenic variation of the capsid pro
Externí odkaz:
https://doaj.org/article/5e300d1bf6fb4671b8915ee2ab579d6b
Autor:
Xiaomin Wang, Yanhui Liang, Jianping Zhao, Yuan Li, Shixue Gou, Min Zheng, Juanjuan Zhou, Quanjun Zhang, Jidong Mi, Liangxue Lai
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/5a91b45d5846462e9660a04cffcff8f6
Autor:
Zhiwei Qin, Liang Xue, Weicheng Cai, Junshan Gao, Yueting Jiang, Jiale Yang, Yanhui Liang, Linping Wang, Jumei Zhang, Yongdan Hu, Qingping Wu
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Human noroviruses are one of the main causes of foodborne illnesses and represent a serious public health concern. Rapid and sensitive assays for human norovirus detection are undoubtedly necessary for clinical diagnosis, especial
Externí odkaz:
https://doaj.org/article/7e1837e1ac084d8cb6a675a76e50a18a
Autor:
Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang, Liangxue Lai
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or a
Externí odkaz:
https://doaj.org/article/5974bfd9c0c64e52a24cfd1869de793b
Autor:
Yueting Zuo, Liang Xue, Junshan Gao, Yingyin Liao, Yueting Jiang, Ying Li, Yanhui Liang, Linping Wang, Weicheng Cai, Tong Cheng, Juan Wang, Moutong Chen, Jumei Zhang, Yu Ding, Qingping Wu
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Foodbone norovirus (NoV) is the leading cause of acute gastroenteritis worldwide. Candidate vaccines are being developed, however, no licensed vaccines are currently available for managing NoV infections. Screening for stimulated antibodies with broa
Externí odkaz:
https://doaj.org/article/f2e923e9d3a54f5592f0bab474c14c7f
Autor:
Junshan Gao, Le Zhang, Liang Xue, Weicheng Cai, Zhiwei Qin, Jiale Yang, Yanhui Liang, Linping Wang, Moutong Chen, Qinghua Ye, Ying Li, Juan Wang, Shi Wu, Qingping Wu, Jumei Zhang
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Human norovirus is a common cause of acute gastroenteritis worldwide, and oysters have been found to be the main carriers for its spread. The lack of efficient pre-treatment methods has been a major bottleneck limiting the detection of viruses in oys
Externí odkaz:
https://doaj.org/article/8f36559a113b42559292928bf952e6c0