Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yanhua Rao"'
Publikováno v:
Cancer Research. 83:3707-3707
Studies presented here were conducted to validate UXS1 as a synthetic lethal target in UGDHhigh expressing cancer. In vitro and in vivo knockout studies were used to investigate the role of UXS1 in UGDH-high cancers. UXS1 has been validated as a synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2939170fa92943cf6c642fd792c47770
https://doi.org/10.1158/1538-7445.am2023-3707
https://doi.org/10.1158/1538-7445.am2023-3707
Autor:
Yanhua Rao, Anjana Srivatsan, Marya Liimatta, Diana Munoz, Jeanne Quirit, Jianxia Shi, An Nguyen, Xin Linghu, Federowicz Federowicz, Brian Jones, Melissa Fleury, Zach Newby, Michael P. Dillon, Paul A. Barsanti, Mark R. Lackner, Michael A. White, Yang Lee, Phil Landis, Yang Peng, Michelle Cicchini, Josh Cottom, Leng Nickels, Ed Brnardic, Michael DeMartino, Josh Taygerly
Publikováno v:
Cancer Research. 83:1628-1628
Werner syndrome protein (WRN) is a RecQ-family helicase involved in the maintenance of genome integrity. Germline mutations in WRN cause premature aging and cancer predisposition. Analysis of systematic RNAi and CRISPR screening data has previously r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15196273d127bc0ec3c0b9c164a7c0c9
https://doi.org/10.1158/1538-7445.am2023-1628
https://doi.org/10.1158/1538-7445.am2023-1628
Autor:
Livio Trusolino, David A. Jackson, Francesco Iorio, Dieudonne van der Meer, Gabriele Picco, Julio Saez-Rodriguez, Emanuel Gonçalves, Charlotte M. Beaver, Fiona M. Behan, Yanhua Rao, Sarah Harper, Mathew J. Garnett, Giorgia Migliardi, Marika Pinnelli, Euan A. Stronach, Rachel Pooley, Rebecca McRae, Francesco Sassi, Kosuke Yusa, Carolyn Buser-Doepner, Rita Santos, Piers Wilkinson, Rizwan Ansari, David J. Dow, Andrea Bertotti
Publikováno v:
Nature
Functional genomics approaches can overcome limitations—such as the lack of identification of robust targets and poor clinical efficacy—that hamper cancer drug development. Here we performed genome-scale CRISPR–Cas9 screens in 324 human cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03f6d7e8b782dcf7803152899bb75e8
https://doi.org/10.1038/s41586-019-1103-9
https://doi.org/10.1038/s41586-019-1103-9
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114087 (2014)
Primary cilia are specialized, acetylated microtubule-based signaling processes. Cilium assembly is activated by cellular quiescence and requires reconfiguration of microtubules, the actin cytoskeleton, and vesicular trafficking machinery. How these
Externí odkaz:
https://doaj.org/article/e2b3600f9ee345e5b5d1dc0f9dd485ae
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89288 (2014)
BACKGROUND: Conclusions drawn from meta-analyses on the association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women are not fully consistent. These meta-analyses did not explore the influence of different study
Externí odkaz:
https://doaj.org/article/da70535b57d74f03ae785d43d88de105
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36497 (2012)
PURPOSE: The purpose of this study was to explore the risk factors for breast cancer and establish the expression rate of IGF-2 in female patients. METHODS: A case control study with 500 people in case group and 500 people in control group. A self-ad
Externí odkaz:
https://doaj.org/article/36e1d24fcdcc4036891b5d8b943fce98
Autor:
Adolfo Alfonso-Pecchio, Wangfang Hou, Stephen S. Wilson, Quinn Lu, Shu Zhang, Michelle L. Kimberland, Yanhua Rao
Publikováno v:
Journal of Biotechnology. 284:91-101
The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular systems for studying phenotypic effects of genetic perturbations. However, with this technology comes the inherent risk of generating off-target effects (OTEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471260f5e73a16c8827f81dbfb0b5ab
https://doi.org/10.1016/j.jbiotec.2018.08.007
https://doi.org/10.1016/j.jbiotec.2018.08.007
Autor:
Fiona M, Behan, Francesco, Iorio, Gabriele, Picco, Emanuel, Gonçalves, Charlotte M, Beaver, Giorgia, Migliardi, Rita, Santos, Yanhua, Rao, Francesco, Sassi, Marika, Pinnelli, Rizwan, Ansari, Sarah, Harper, David Adam, Jackson, Rebecca, McRae, Rachel, Pooley, Piers, Wilkinson, Dieudonne, van der Meer, David, Dow, Carolyn, Buser-Doepner, Andrea, Bertotti, Livio, Trusolino, Euan A, Stronach, Julio, Saez-Rodriguez, Kosuke, Yusa, Mathew J, Garnett
Functional genomics approaches can overcome limitations-such as the lack of identification of robust targets and poor clinical efficacy-that hamper cancer drug development. Here we performed genome-scale CRISPR-Cas9 screens in 324 human cancer cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e4160865bd30041e8ccfb533580ca27
http://hdl.handle.net/2318/1714058
http://hdl.handle.net/2318/1714058
Autor:
David J. Dow, Carolyn Buser-Doepner, Euan A. Stronach, Emanuel Gonçalves, Rachel Pooley, Mathew J. Garnett, Sarah Harper, Rebecca McRae, Piers Wilkinson, David A. Jackson, Charlotte M. Beaver, Kosuke Yusa, Yanhua Rao, Francesco Iorio, Gabriele Picco, Rizwan Ansari, Fiona M. Behan, Julio Saez-Rodriguez, Rita Santos
SummaryFunctional genomics approaches can overcome current limitations that hamper oncology drug development such as lack of robust target identification and clinical efficacy. Here we performed genome-scale CRISPR-Cas9 screens in 204 human cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dc8dfa7784cfc9ae07f20c623379d3
Autor:
Coco Dong, Junping Jing, Benjamin Schwartz, David G. Cooper, Mugdha Khaladkar, Stefanie Riesenberg, Sarah A. Middleton, Yanhua Rao, Boris Wilson, Usman Shabon, Euan Stronach
Publikováno v:
Cancer Research. 78:2344-2344
Although most canonical somatic cancer mutations have now been cataloged, only a fraction are amenable to drug discovery efforts. These are limited to targets with gain of function mutations and druggable protein domains. Examples include kinases suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4294641800ebffa000c776605dd71391
https://doi.org/10.1158/1538-7445.am2018-2344
https://doi.org/10.1158/1538-7445.am2018-2344