Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Yanhua H. Huang"'
Autor:
Terra A. Schall, King-Lun Li, Xiguang Qi, Brian T. Lee, William J. Wright, Erin E. Alpaugh, Rachel J. Zhao, Jianwei Liu, Qize Li, Bo Zeng, Lirong Wang, Yanhua H. Huang, Oliver M. Schlüter, Eric J. Nestler, Edward H. Nieh, Yan Dong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable “free-willed” animals to obtain rewards remain elusive. Here, we recorded Ca2+ activity from individual NAc neurons whe
Externí odkaz:
https://doaj.org/article/c920ef88213f4bce8e1c2588cffc342d
Autor:
Sabrina Villar-Pazos, Laurel Thomas, Yunhan Yang, Kun Chen, Jenea B. Lyles, Bradley J. Deitch, Joseph Ochaba, Karen Ling, Berit Powers, Sebastien Gingras, Holly B. Kordasiewicz, Melanie J. Grubisha, Yanhua H. Huang, Gary Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1R203W)). The mechanism by which PACS1R203W causes PACS1 syndrome is unknown, and no curative treatment is avail
Externí odkaz:
https://doaj.org/article/7e51f4e4e1ae4bf299cf150d16ad4576
Publikováno v:
eLife, Vol 12 (2023)
In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus [CS]) also gain incentive salience to promote drug seeking. The basolateral amygdala (BLA) is implicated
Externí odkaz:
https://doaj.org/article/0092cca3e380451d8777179ba874f016
Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior
Autor:
Darius D. Becker-Krail, Kyle D. Ketchesin, Jennifer N. Burns, Wei Zong, Mariah A. Hildebrand, Lauren M. DePoy, Chelsea A. Vadnie, George C. Tseng, Ryan W. Logan, Yanhua H. Huang, Colleen A. McClung
Publikováno v:
Biol Psychiatry
BACKGROUND: Substance use disorders (SUDs) are associated with disruptions in circadian rhythms. Both human and animal work has shown the integral role for circadian clocks in the modulation of reward behaviors. Interestingly, astrocytes have emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fa48ae0094260e4fb29f3ec81c2ffd
https://doi.org/10.1016/j.biopsych.2022.02.007
https://doi.org/10.1016/j.biopsych.2022.02.007
Autor:
Terry Chao, Junshi Wang, Yao Wang, Xiaojie Huang, Yan Dong, Lily E. Kramer, Susan R. Sesack, Masago Ishikawa, Hugh H. Huang, Eric J. Nestler, Oliver M. Schlüter, Avani Shukla, Ania Beroun, King-Lun Li, Yanhua H. Huang, Yao Q. Wang, Yue Yang, Noah D. Bastola
Publikováno v:
Biological Psychiatry. 89:386-397
Background Synaptogenesis is essential in forming new neurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, α2δ-1. Here, we show that this developmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e39be89dbec2d67fb6b428adcfba6c1
https://doi.org/10.1016/j.biopsych.2020.08.012
https://doi.org/10.1016/j.biopsych.2020.08.012
Autor:
Howard B. Gutstein, Jun-Li Cao, Oliver M. Schlüter, Yao Q. Wang, Junshi Wang, Sun-hui Xia, Yan Dong, Yanhua H. Huang
Publikováno v:
Pain. 162:1322-1333
Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, the underlying circuit mechanisms remain underexplored. Here, we focus on pain-induced remodeling of the projection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2156d1545ea3ed256e2490e723f41cd5
https://doi.org/10.1097/j.pain.0000000000002149
https://doi.org/10.1097/j.pain.0000000000002149
Autor:
Yao Wang, Rong Guo, Tanbin Rahman, George C. Tseng, Jidong Fang, Yan Dong, Marianne L. Seney, Bo Chen, Yanhua H. Huang, Li Cai, Yizhi Li
Publikováno v:
Molecular psychiatry
Sleep abnormalities are often a prominent contributor to withdrawal symptoms following chronic drug use. Notably, rapid eye movement (REM) sleep regulates emotional memory, and persistent REM sleep impairment after cocaine withdrawal negatively impac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dae18c533353beafede77878c17e7b
https://doi.org/10.1038/s41380-020-00921-1
https://doi.org/10.1038/s41380-020-00921-1
Autor:
Rong Guo, Yao Wang, Rongzhen Yan, Bo Chen, Wanqiao Ding, Michael T. Gorczyca, Sahin Ozsoy, Li Cai, Rachel L. Hines, George C. Tseng, Giancarlo Allocca, Yan Dong, Jidong Fang, Yanhua H. Huang
Publikováno v:
Biological psychiatry. 92(11)
Persistent sleep disruptions following withdrawal from abused drugs may hold keys to battle drug relapse. It is posited that there may be sleep signatures that predict relapse propensity, identifying which may open new avenues for treating substance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6e52904ba324eb079db03093424276
https://pubmed.ncbi.nlm.nih.gov/36328704
https://pubmed.ncbi.nlm.nih.gov/36328704
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63cb9b09c2f102d0a2ab0ea240959359
https://doi.org/10.3791/63185-v
https://doi.org/10.3791/63185-v
Publikováno v:
J Neurosci
Interfering with memory reconsolidation or inducing memory extinction are two approaches for weakening maladaptive memories in disorders such as addiction and post-traumatic stress disorder. Both extinction and reconsolidation are regulated by intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505905a527ce8eb9d56a65cbfa5b275c
https://doi.org/10.1523/jneurosci.0453-19.2019
https://doi.org/10.1523/jneurosci.0453-19.2019