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Akademický článek

The relevance of food composition data for nutrition surveys in rural Tibet: pilot study in the context of Kashin-Beck Disease

Autor: Dermience, M., Mathieu, F., Barthélemy, JP., Maesen, P., Romnee, JM., De Maertelaer, V., Yangzom, D., Tsewang, P., Lognay, G.

Publikováno v: Biotechnologie, Agronomie, Société et Environnement, Vol 17, Iss 1, Pp 32-42 (2013)

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People's Republic of China. The etiology of the disease remains obscure although env

Externí odkaz: https://doaj.org/article/536f2eb680094142a4b1bdf6018fec6f

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Akademický článek

Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer

Autor: Tyler Sniegowski, Devaraja Rajasekaran, Souad R. Sennoune, Sukumaran Sunitha, Fang Chen, Mohamed Fokar, Sudhir Kshirsagar, P. Hemachandra Reddy, Ksenija Korac, Mosharaf Mahmud Syed, Tanima Sharker, Vadivel Ganapathy, Yangzom D. Bhutia

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Pancreatic ductal adenocarcinoma (PDAC) cells have a great demand for nutrients in the form of sugars, amino acids, and lipids. Particularly, amino acids are critical for cancer growth and, as intermediates, connect glucose, lipid and nucleo

Externí odkaz: https://doaj.org/article/8da0a1c1200e43b09d36b442c5a114e9

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Akademický článek

Clinical and Radiological Features Between Patients with Stable COPD from Plateau and Flatlands: A Comparative Study

Autor: Jiang Z, Wang X, Zhang L, Yangzom D, Ning Y, Su B, Li M, ChuTso M, Chen Y, Liang Y, Sun Y

Publikováno v: International Journal of COPD, Vol Volume 18, Pp 849-858 (2023)

Zhihan Jiang,1,* Xiaosen Wang,1,* Lijiao Zhang,1,* Drolma Yangzom,2,* Yanping Ning,2 Baiyan Su,3,4 Meijiao Li,5 Meilang ChuTso,2 Yahong Chen,1,6 Ying Liang,1,2,6 Yongchang Sun1,6 1Department of Respiratory and Critical Care Medicine,

Externí odkaz: https://doaj.org/article/4e82037ec4ee48ed80e86a2865fd6640

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Akademický článek

Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential Effects on These Two Processes

Autor: Nhi T. Nguyen, Souad R. Sennoune, Gunadharini Dharmalingam-Nandagopal, Sathish Sivaprakasam, Yangzom D. Bhutia, Vadivel Ganapathy

Publikováno v: Cells, Vol 13, Iss 11, p 951 (2024)

Mutations in p53 and KRAS are seen in most cases of colon cancer. The impact of these mutations on signaling pathways related to cancer growth has been studied in depth, but relatively less is known on their effects on amino acid transporters in canc

Externí odkaz: https://doaj.org/article/e78e0cc245e34a90a1bcb127b16674cb

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Akademický článek

Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

Autor: Marilyn Mathew, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Souad R. Sennoune, Nhi T. Nguyen, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy

Publikováno v: Antioxidants, Vol 13, Iss 3, p 291 (2024)

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A1

Externí odkaz: https://doaj.org/article/3daedfbc71a246f0a273bad44bddad1d

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Akademický článek

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Akademický článek

Clinical and Radiological Features of COPD Patients Living at ≥3000 m Above Sea Level in the Tibet Plateau

Autor: Liang Y, Yangzom D, Tsokyi L, Ning Y, Su B, Luo S, Ma Cuo B, ChuTso M, Ding Y, Chen Y, Sun Y

Publikováno v: International Journal of COPD, Vol Volume 16, Pp 2445-2454 (2021)

Ying Liang,1,2 Drolma Yangzom,2 Lhamo Tsokyi,2 Yanping Ning,2 Baiyan Su,3,4 Shuai Luo,4 Bian Ma Cuo,2 Meilang ChuTso,2 Yanling Ding,1 Yahong Chen,1 Yongchang Sun1 1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital

Externí odkaz: https://doaj.org/article/0dc75ded0c204bc8a0d6ee6623d64a5c

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Akademický článek

Sertoli Cells Express Accommodation, Survival, and Immunoregulatory Factors When Exposed to Normal Human Serum

Autor: Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour

Publikováno v: Biomedicines, Vol 11, Iss 6, p 1650 (2023)

Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte

Externí odkaz: https://doaj.org/article/b54c88465c0646c0ae6edfd99d7c02ae

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