Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yangzhong Tang"'
Autor:
Fernando Rodríguez Pérez, Dean Natwick, Lauren Schiff, David McSwiggen, Alec Heckert, Melina Huey, Huntly Morrison, Mandy Loo, Rafael G. Miranda, John Filbin, Jose Ortega, Kayla Van Buren, Danny Murnock, Arnold Tao, Renee Butler, Kylie Cheng, William Tarvestad, Zhengjian Zhang, Eric Gonzalez, Rand M. Miller, Marcus Kelly, Yangzhong Tang, Jaclyn Ho, Daniel Anderson, Charlene Bashore, Stephen Basham
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Synthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival. However,
Externí odkaz:
https://doaj.org/article/ce2bc19584424ac1a3b0cff592d3ad30
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. S1 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0595d9ccc193c5c4dd6436ba0d3685f7
https://doi.org/10.1158/1535-7163.22483554
https://doi.org/10.1158/1535-7163.22483554
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Methods from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4016373736a2af88b93a483de1380
https://doi.org/10.1158/1535-7163.22483524
https://doi.org/10.1158/1535-7163.22483524
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Table S3 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4404bcc724ec46d0dc423beee96d7d8a
https://doi.org/10.1158/1535-7163.22483515
https://doi.org/10.1158/1535-7163.22483515
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458dcb870e35eaa46251de3f99e9798
https://doi.org/10.1158/1535-7163.c.6531162
https://doi.org/10.1158/1535-7163.c.6531162
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b3ed18a9fbe5dab79cee17aedfa7a
https://doi.org/10.1158/1535-7163.22483527.v1
https://doi.org/10.1158/1535-7163.22483527.v1
Autor:
David T. McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B. Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J. Ho, Stephanie L. Johnson, Reed Kelso, Aaron Klammer, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Lawrence Meyer, Sarah E. Pierce, Akshay Sule, Yangzhong Tang, Daniel J. Anderson, Hilary P. Beck
The regulation of cell physiology largely depends upon intracellular interactions of functionally distinct proteins that act in combination. These interactions, which are often transient in nature, help to define the motion profiles of proteins. Meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac3d8c0262997dae5851a5a2a6172235
https://doi.org/10.1101/2023.01.05.522916
https://doi.org/10.1101/2023.01.05.522916
Autor:
Amy Saur Conway, Lina Benajiba, Camille Vaganay, Daniel J. DeAngelo, Olivier Hermine, Yangzhong Tang, Kasper Lage, Han-Jie Zhou, Ilene Galinsky, Patrick Auberger, Jesse D. Vargas, Richard Stone, Josée Guirouilh-Barbat, Gabriela Alexe, Chaïma Benaksas, Yana Pikman, Alexandre Puissant, Bryann Pardieu, Daniel Anderson, Kimberly Stegmaier, Blandine Roux, Jana M. Ellegast, Bernard S. Lopez, Monica Schenone, Christina R. Hartigan, Michael T. Hemann, Linda Ross, Nina Fenouille, Mehdi Khaled, Frank Ling, Edyta Malolepsza, Frederic Luciano, Steven A. Carr, Gaetano Sodaro, Ronan Le Moigne, Tony Wu
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩
Sci Transl Med
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩
Sci Transl Med
The development and survival of cancer cells require adaptive mechanisms to stress. Such adaptations can confer intrinsic vulnerabilities, enabling the selective targeting of cancer cells. Through a pooled in vivo short hairpin RNA (shRNA) screen, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10c3d1c692e60e789dde8f10a34b3af
https://hal.archives-ouvertes.fr/hal-03420708
https://hal.archives-ouvertes.fr/hal-03420708
Autor:
Jesse D. Vargas, Kenny Lou, Kristy C. Perez, Han-Jie Zhou, Yangzhong Tang, Mary-Kamala Menon, Mark Rolfe, Ronan Le Moigne, Xianyun Jiao, Peter K Buchowiecki, Ariel Pios, Antonett Madriaga, Daniel Anderson, Grace J. Lee, Bing Yao, Laura K. Shawver, Zhi Yong Wu, Victoria A. Assimon
Publikováno v:
ACS chemical biology. 14(2)
RUVBL1 and RUVBL2 are ATPases associated with diverse cellular activities (AAAs) that form a complex involved in a variety of cellular processes, including chromatin remodeling and regulation of gene expression. RUVBLs have a strong link to oncogenes
Autor:
Jade Shi, Claudia Wilm, Frank Zenke, Clement T. Loy, Timothy J. Mitchison, Yangzhong Tang, Christiane Amendt, James D. Orth
Publikováno v:
Molecular Cancer Therapeutics. 7:3480-3489
Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microsco