Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35

Autor: Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xinheng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang

Publikováno v: Cell Discovery, Vol 8, Iss 1, Pp 1-12 (2022)

Abstract Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes Gs, Gi/o, and Gq/11, insufficient structural evidence is

Externí odkaz: https://doaj.org/article/9238d676dc194b6688aba66ae2be41d2

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Autor: Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen

Publikováno v: Cell Discovery, Vol 8, Iss 1, Pp 1-11 (2022)

Abstract Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes:

Externí odkaz: https://doaj.org/article/ddfaf8d72624436ea3ba8d6100f0cbf8

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

Autor: Sijie Huang, Peiyu Xu, Dan-Dan Shen, Icaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam, H. Eric Xu

Publikováno v: Huang, S, Xu, P, Shen, D D, Simon, I A, Mao, C, Tan, Y, Zhang, H, Harpsøe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D E & Xu, H E 2022, ' GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors ', Molecular cell, vol. 82, no. 14, pp. 2681-2695.e6 . https://doi.org/10.1016/j.molcel.2022.05.031
Molecular cell, 82(14), 2681-2695.e6. Cell Press

Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of Gs, Gi, or Gq proteins. The structural basis for G protein subtype selectivity by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c14e6f3505ee05c519a1463efa9c29
https://hdl.handle.net/1871.1/713d857a-269d-42a6-a385-466fed3a7d58

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Autor: Peiyu Xu, Jia Duan, Yan Zhang, Xinheng He, Yangxia Tan, Sijie Huang, X. Edward Zhou, H. Eric Xu, Karsten Melcher, Dan-Dan Shen, Huibing Zhang, Youwen Zhuang, Qiufeng Liu, Yi Jiang, Shanshan Ma, Peng Bi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications

Vasoactive intestinal polypeptide receptor (VIP1R) is a widely expressed class B G protein-coupled receptor and a drug target for the treatment of neuronal, metabolic, and inflammatory diseases. However, our understanding of its mechanism of action a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f14e085691c8dee226c4bb42fac917
http://link.springer.com/article/10.1038/s41467-020-17933-8

GPCRs steer G

Autor: Sijie, Huang, Peiyu, Xu, Dan-Dan, Shen, Icaro A, Simon, Chunyou, Mao, Yangxia, Tan, Huibing, Zhang, Kasper, Harpsøe, Huadong, Li, Yumu, Zhang, Chongzhao, You, Xuekui, Yu, Yi, Jiang, Yan, Zhang, David E, Gloriam, H Eric, Xu

Publikováno v: Molecular cell. 82(14)

Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d0c441213f48aaff5ea42671a756862
https://pubmed.ncbi.nlm.nih.gov/35714614