Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yangwei J. Pu"'
Autor:
James P. Wepsiec, D. Scott Coffey, Amy C. DeBaillie, Lin Wang, Iwona A. Kaluzna, Spiros Kambourakis, Nicholas A. Magnus, Chauncey D. Jones, Yangwei J. Pu
Publikováno v:
Organic Process Research & Development. 15:1377-1381
This communication describes proof of concept for an enantioselective enzyme-based synthesis of diarylmethanol (S)-1 to access mGlu2 receptor potentiators. A ketoreductase (KRED) screen was applied to benzophenone 8 to afford chiral diarylmethanol (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607b8509d767e330d1083ce50e93e5c9
https://doi.org/10.1021/op2002479
https://doi.org/10.1021/op2002479
Autor:
Yangwei J. Pu, Everett J. Perkins, William D. Diseroad, David M. Bender, Anne H. Dantzig, Jeffrey A. Peterson, Deyi Zhang, Jingqi Bao, Kevin L. Law, Radhe K. Vaid, Nicholas A. Magnus, David Michael Remick, Mccarthy James R, Gregory A. Stephenson, Susan M. Reutzel-Edens, James J. Starling
Publikováno v:
Journal of Medicinal Chemistry. 52:6958-6961
The design, synthesis, and biological characterization of an orally active prodrug (3) of gemcitabine are described. Additionally, the identification of a novel co-crystal solid form of the compound is presented. Valproate amide 3 is orally bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6826ce1900e7d8561ae2eb5ee2eacd99
https://doi.org/10.1021/jm901181h
https://doi.org/10.1021/jm901181h
Diarylketone Ketoreductase Screen and Synthesis Demonstration to Access mGlu2 Receptor Potentiators.
Autor:
Nicholas A. Magnus, D. Scott Coffey, Amy C. DeBaillie, Chauncey D. Jones, Iwona A. Kaluzna, Spiros Kambourakis, Yangwei J. Pu, Lin Wang, James P. Wepsiec
Publikováno v:
Organic Process Research & Development; Nov2011, Vol. 15 Issue 6, p1377-1381, 5p
Autor:
David M. Bender, Jingqi Bao, Anne H. Dantzig, William D. Diseroad, Kevin L. Law, Nicholas A. Magnus, Jeffrey A. Peterson, Everett J. Perkins, Yangwei J. Pu, Susan M. Reutzel-Edens, David M. Remick, James J. Starling, Gregory A. Stephenson, Radhe K. Vaid, Deyi Zhang, James R. McCarthy
Publikováno v:
Journal of Medicinal Chemistry; Nov2009, Vol. 52 Issue 22, p6958-6961, 4p