Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yanguo, Shang"'
Autor:
Zhongwei Mao, Hongying Xiao, Panpan Shen, Yu Yang, Jing Xue, Yunyun Yang, Yanguo Shang, Lilan Zhang, Xin Li, Yuying Zhang, Yanan Du, Chun-Chi Chen, Rey-Ting Guo, Yonghui Zhang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract KRAS mutation occurs in nearly 30% of human cancers, yet the most prevalent and oncogenic KRAS(G12D) variant still lacks inhibitors. Herein, we designed a series of potent inhibitors that can form a salt bridge with KRAS’s Asp12 residue. O
Externí odkaz:
https://doaj.org/article/b89d9fc49b0d496ab0b69418cf6827ab
Publikováno v:
Journal of Craniofacial Surgery; Jun2024, Vol. 35 Issue 4, p1152-1156, 5p
Publikováno v:
Operative Neurosurgery. 24:301-309
Autor:
Maohua, Ding, Xu, Wang, Haijun, Zhao, Minggang, Shi, Yanguo, Shang, Hu, Wang, Xuan, Wang, Xiaoguang, Tong
Publikováno v:
World Neurosurgery. 164:e662-e670
The optimal management of giant internal carotid aneurysms (GICAs) is disputed owing to their low incidence. The aim of this study was to describe the use of internal carotid artery (ICA) constriction as therapeutic management of GICAs.This retrospec
Autor:
Wenqiang Guo, Hu Wang, Yanguo Shang, Minggang Shi, Xuan Wang, Xingdong Wang, Jingang Bao, Zhiqiang Wang, Xiaoguang Tong
Publikováno v:
Neurosurgical Review. 46
Autor:
Yanguo Shang, Minghui Wang, Qingjing Hao, Tao Meng, Lili Li, Junwei Shi, Guoqing Yang, Zhilan Zhang, Kan Yang, Jinxin Wang
Publikováno v:
Bioorganic chemistry. 128
Fatty acid amide hydrolase (FAAH), aserinehydrolase with significant role in thehydrolysis of endocannabinoids, is a promising therapeutic target for peripheral and central nervous system related disorders, including pain, neuroinflammation and depre
Publikováno v:
Operative Neurosurgery. 19:117-125
Background The use of bypass surgery for anterior communicating artery (ACOM) aneurysms is technically challenging. Communicating bypass (COMB), such as pericallosal artery side-to-side anastomosis, is the most frequently used and anatomically direct
Autor:
Zhongwei Mao, Hongying Xiao, Panpan Shen, Yu Yang, Jing Xue, Yunyun Yang, Yanguo Shang, Lilan Zhang, Xin Li, Yuying Zhang, Yanan Du, Chun-Chi Chen, Rey-Ting Guo, Yonghui Zhang
KRAS mutation occurs in nearly 30% of human cancers, yet the most prevalent and oncogenic KRAS mutation (G12D) still lacks inhibitors. Herein, we explored the formation of a salt-bridge between KRAS’s Asp12 residue and a series of potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129847c0bcadb7e02df56727901ed094
https://doi.org/10.1101/2021.12.13.472365
https://doi.org/10.1101/2021.12.13.472365
Publikováno v:
World neurosurgery. 159
Posterior cerebral artery (PCA) aneurysms are rare, and most are giant, dissecting, or fusiform in morphology. Proximal occlusion of the PCA without revascularization causes high risk of ischemic complications. This study aimed to evaluate the safety
Autor:
Zhong Liu, Qingjing Hao, Gui-min Zhang, Jinxin Wang, Yanguo Shang, Jing-chun Yao, Wenting Zhang, Jie Li, Zhi Zhuo'er, Yu-shan Ren
Publikováno v:
Journal of medicinal chemistry. 63(11)
Most of the current monoacylglycerol lipase (MAGL) inhibitors function by an irreversible mechanism of action, causing a series of side effects. Herein, starting from irreversible inhibitors, 25 compounds were synthesized and evaluated in vitro for M