Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yangshin Park"'
Autor:
Jared Sivinski, Andrew J. Ambrose, Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Niloufar Mollasalehi, Lynn K. Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park, Chunxiang Wu, Quyen Q. Hoang, Steven M. Johnson, Eli Chapman
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
The GroES/GroEL chaperonin from E. coli
Externí odkaz:
https://doaj.org/article/ebd31eb709974744bdcf006fa3005b0d
Autor:
Guido J. Breedveld, Anneke J.A. Kievit, Leon de Boer, Murat Emre, Hasmet Hanagasi, Federico Ferraro, Ebba Lohmann, Yangshin Park, Wei Wang, Gregory A. Petsko, Christina Fevga, Quyen Q. Hoang, Rick van Minkelen, Agnita J.W. Boon, Vincenzo Bonifati
Publikováno v:
Parkinsonism and Related Disorders, 89, 63-72. Elsevier
Parkinsonism & related disorders
Parkinsonism & related disorders
Introduction: Missense variants and multiplications of the alpha-synuclein gene (SNCA) are established as rare causes of autosomal dominant forms of Parkinson's Disease (PD). Methods: Two families of Turkish origins with PD were studied; the SNCA cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1836333235429591102cdc25fbe7340
http://www.scopus.com/inward/record.url?scp=85109019740&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85109019740&partnerID=8YFLogxK
Publikováno v:
Trends in biochemical sciences. 47(12)
Mutation in leucine-rich repeat (LRR) kinase 2 (LRRK2) is a common cause of Parkinson's disease (PD). Aberrant LRRK2 kinase activity is associated with disease pathogenesis and thus it is an attractive drug target for combating PD. Intense efforts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda7465ceb6f413593e4e0b3c3fa025c
https://pubmed.ncbi.nlm.nih.gov/35840518
https://pubmed.ncbi.nlm.nih.gov/35840518
Autor:
Jared Sivinski, Duc Ngo, Christopher J. Zerio, Andrew J. Ambrose, Edmond R. Watson, Lynn K. Kaneko, Marius M. Kostelic, Mckayla Stevens, Anne‐Marie Ray, Yangshin Park, Chunxiang Wu, Michael T. Marty, Quyen Q. Hoang, Donna D. Zhang, Gabriel C. Lander, Steven M. Johnson, Eli Chapman
Publikováno v:
FASEB J
GroES/GroEL is the only bacterial chaperone essential under all conditions, making it a potential antibiotic target. Rationally targeting ESKAPE GroES/GroEL as an antibiotic strategy necessitates studying their structure and function. Herein, we outl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fdbcdf0cdf11d1c334ee2fd902172a
https://doi.org/10.1096/fj.202101708rr
https://doi.org/10.1096/fj.202101708rr
Autor:
Anne-Marie Ray, Tanya Parish, Yulia Ovechkina, Jared Sivinski, Steven M. Johnson, Siddhi Chitre, Yangshin Park, Eli Chapman, Mckayla Stevens, James Johnson, Quyen Q. Hoang, Alex Washburn, Sanofar Abdeen
Publikováno v:
Bioorg Med Chem Lett
Current treatments for Mycobacterium tuberculosis infections require long and complicated regimens that can lead to patient non-compliance, increasing incidences of antibiotic-resistant strains, and lack of efficacy against latent stages of disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000bc8e2afa8fcd9aff724ab32e262c4
https://doi.org/10.1016/j.bmcl.2019.04.034
https://doi.org/10.1016/j.bmcl.2019.04.034
Autor:
Sanofar Abdeen, Nilshad Salim, Jared Sivinski, Mckayla Stevens, Siddhi Chitre, Eli Chapman, Anne-Marie Ray, Quyen Q. Hoang, Steven M. Johnson, Alex Washburn, Yangshin Park
Publikováno v:
Bioorg Med Chem Lett
All living organisms contain a unique class of molecular chaperones called 60 kDa heat shock proteins (HSP60 – also known as GroEL in bacteria). While some organisms contain more than one HSP60 or GroEL isoform, at least one isoform has always prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf0c41ab3fe19e9b67203627d87ce61
https://doi.org/10.1016/j.bmcl.2019.02.028
https://doi.org/10.1016/j.bmcl.2019.02.028
Publikováno v:
The FASEB Journal. 33:4814-4823
Parkinson disease–associated mutations within the GTPase domain Ras of complex proteins (ROC) of leucine rich repeat kinase 2 (LRRK2) result in an abnormal over-activation of its kinase domain. However, the mechanisms involved remain unclear. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e982ada5e4dbdf6f6781a0eb784834ed
https://doi.org/10.1096/fj.201802031r
https://doi.org/10.1096/fj.201802031r
Autor:
Iliya Panfilenko, Christopher J. Zerio, Jason M. Machulis, Yangshin Park, Eli Chapman, Chun-Xiang Wu, Andrew J. Ambrose, Mckayla Stevens, Lynn Kaneko, Steven M. Johnson, Niloufar Mollasalehi, Jared Sivinski, Anne-Marie Ray, Quyen Q. Hoang
Publikováno v:
mBio
mBio, Vol 12, Iss 1 (2021)
mBio, Vol 12, Iss 1 (2021)
The GroES/GroEL chaperonin from E. coli has long served as the model system for other chaperonins. This assumption seemed valid because of the high conservation between the chaperonins.
As the GroES/GroEL chaperonin system is the only bacterial
As the GroES/GroEL chaperonin system is the only bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75306fc2ba6b09d71878d59f9c62a71b
https://pubmed.ncbi.nlm.nih.gov/33436430
https://pubmed.ncbi.nlm.nih.gov/33436430
Autor:
Siddhi Chitre, Mckayla Stevens, Eli Chapman, Jared Sivinski, Yangshin Park, Anne-Marie Ray, Quyen Q. Hoang, Alex Washburn, Steven M. Johnson, Chris Howe
Publikováno v:
Bioorg Med Chem
In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a9b20c557c56eae7acde5fd5c05616
https://europepmc.org/articles/PMC7914298/
https://europepmc.org/articles/PMC7914298/
Autor:
Yangshin Park, Anne-Marie Ray, Peter G. Schultz, Quyen Q. Hoang, Nilshad Salim, Steven M. Johnson, Andrew J. Ambrose, Najiba Mammadova, Corey M. Summers, Eli Chapman, Trent Kunkle, Mckayla Stevens, Sanofar Abdeen, Arthur L. Horwich
Publikováno v:
Journal of Medicinal Chemistry. 61:7345-7357
Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-symmetrical bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asymmetric a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f789eb0213fc8a1e401a5da134cce909
https://doi.org/10.1021/acs.jmedchem.8b00989
https://doi.org/10.1021/acs.jmedchem.8b00989